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isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

Summary

Gene Symbol

IDH3A

Aliases

H-IDH alpha
NAD(H)-specific isocitrate dehydrogenase alpha subunit
NAD+-specific ICDH
isocitrate dehydrogenase (NAD+) alpha chain
isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
isocitric dehydrogenase

Organism

Homo sapiens (human)

External Links

NCBI Gene

3419

HGNC

5384

KEGG Gene ID

hsa:3419

PubChem

3419

Alliance of Genome Resources

HGNC:5384

JoGo

IDH3A

TogoVar

IDH3A

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Direct protein sequencing
Disease variant
Magnesium
Manganese
Metal-binding
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Retinitis pigmentosa
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7Z9J8	Isocitric dehydrogenase subunit alpha NAD(+)-specific ICDH subunit alpha
B4DJB4
P50213	Isocitric dehydrogenase subunit alpha NAD(+)-specific ICDH subunit alpha

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
carbohydrate metabolic process	NAS
tricarboxylic acid cycle	TAS
tricarboxylic acid cycle	IDA
tricarboxylic acid cycle	IBA
tricarboxylic acid cycle	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

primary metabolic process [inference]

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

isocitrate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

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GO Term	Evidence Code	PMID
nucleus	HDA
mitochondrion	NAS
mitochondrion	IDA
mitochondrion	IBA
mitochondrion	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

tricarboxylic acid cycle heteromeric enzyme complex [inference]

isocitrate dehydrogenase complex (NAD+)

oxidoreductase complex [inference]

isocitrate dehydrogenase complex (NAD+)

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

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GO Term	Evidence Code	PMID
magnesium ion binding	IDA
magnesium ion binding	IEA
isocitrate dehydrogenase (NAD+) activity	EXP
isocitrate dehydrogenase (NAD+) activity	IDA
isocitrate dehydrogenase (NAD+) activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

isocitrate dehydrogenase [NAD(P)+] activity [inference]

isocitrate dehydrogenase (NAD+) activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
isocitrate dehydrogenase (NAD+) activity
isocitrate metabolic process
magnesium ion binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
tricarboxylic acid cycle

Displaying **all 3** entries
InterPro
Isocitrate dehydrogenase NAD-dependent
Isocitrate/isopropylmalate dehydrogenase, conserved site
Isopropylmalate dehydrogenase-like domain

Human Protein Atlas

ENSG00000166411

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00030

Name

isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]

References

10601238

Rhea

RHEA:23632

D-threo-isocitrate + NAD⁺

CO₂ + 2-oxoglutarate + NADH

Enzyme

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112147	retinitis pigmentosa 90	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000035	Abnormal testis morphology
HP:0000135	Hypogonadism
HP:0000405	Conductive hearing impairment
HP:0000407	Sensorineural hearing impairment
HP:0000486	Strabismus
HP:0000501	Glaucoma
HP:0000505	Visual impairment
HP:0000512	Abnormal electroretinogram
HP:0000543	Optic disc pallor