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apolipoprotein C3

Summary

Gene Symbol

APOC3

Organism

Homo sapiens (human)

External Links

NCBI Gene

345

KEGG Gene ID

PubChem

345

Alliance of Genome Resources

HGNC:610

Gene Ontology (GO)

Displaying entries **1 - 5** of 33 in total

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GO Term	Evidence Code	PMID
triglyceride metabolic process	IMP
lipid transport	IDA
lipid transport	IEA
G protein-coupled receptor signaling pathway	IDA
negative regulation of triglyceride catabolic process	IDA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

metabolic process [inference]

catabolic process [inference]

lipid catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

lipoprotein metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

lipid catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

protein metabolic process [inference]

lipoprotein metabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

multicellular organismal process [inference]

plasma lipoprotein particle clearance [inference]

triglyceride-rich lipoprotein particle clearance [inference]

chylomicron remnant clearance

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport

phospholipid transport [inference]

phospholipid efflux

sterol transport [inference]

cholesterol transport [inference]

organophosphate ester transport [inference]

phospholipid transport [inference]

phospholipid efflux

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Rho protein signal transduction [inference]

regulation of Cdc42 protein signal transduction

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol import

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol import

regulation of cholesterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol import

regulation of cholesterol import [inference]

negative regulation of cholesterol import

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol import

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis

regulation of lipid localization [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol import

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol import

regulation of cholesterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol import

regulation of cholesterol import [inference]

negative regulation of cholesterol import

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol import

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

negative regulation of triglyceride catabolic process

negative regulation of lipid metabolic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid catabolic process

negative regulation of triglyceride catabolic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of cellular component organization [inference]

negative regulation of very-low-density lipoprotein particle remodeling

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol import

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

negative regulation of multicellular organismal process [inference]

negative regulation of very-low-density lipoprotein particle remodeling

negative regulation of lipoprotein particle clearance [inference]

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of cholesterol import

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Rho protein signal transduction [inference]

regulation of Cdc42 protein signal transduction

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Rho protein signal transduction [inference]

regulation of Cdc42 protein signal transduction

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

negative regulation of triglyceride catabolic process

negative regulation of lipid metabolic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid catabolic process

negative regulation of triglyceride catabolic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

negative regulation of triglyceride catabolic process

regulation of lipid catabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid catabolic process

negative regulation of triglyceride catabolic process

regulation of ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid metabolic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid catabolic process

negative regulation of triglyceride catabolic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of lipid catabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid catabolic process

negative regulation of triglyceride catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

negative regulation of triglyceride catabolic process

negative regulation of lipid metabolic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of lipid catabolic process

negative regulation of triglyceride catabolic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of cellular component organization [inference]

negative regulation of very-low-density lipoprotein particle remodeling

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

regulation of cellular component organization [inference]

regulation of very-low-density lipoprotein particle remodeling [inference]

negative regulation of very-low-density lipoprotein particle remodeling

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis

negative regulation of cellular component organization [inference]

negative regulation of very-low-density lipoprotein particle remodeling

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis

regulation of multicellular organismal process [inference]

regulation of very-low-density lipoprotein particle remodeling [inference]

negative regulation of very-low-density lipoprotein particle remodeling

regulation of lipoprotein particle clearance [inference]

regulation of very-low-density lipoprotein particle clearance [inference]

negative regulation of very-low-density lipoprotein particle clearance

regulation of high-density lipoprotein particle clearance [inference]

negative regulation of high-density lipoprotein particle clearance

negative regulation of lipoprotein particle clearance [inference]

regulation of low-density lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

negative regulation of multicellular organismal process [inference]

negative regulation of very-low-density lipoprotein particle remodeling

negative regulation of lipoprotein particle clearance [inference]

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
extracellular region	NAS
extracellular region	TAS
extracellular region	IDA
extracellular region	IEA
extracellular region	HDA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

high-density lipoprotein particle [inference]

spherical high-density lipoprotein particle

triglyceride-rich plasma lipoprotein particle [inference]

chylomicron

extracellular protein-containing complex [inference]

plasma lipoprotein particle [inference]

high-density lipoprotein particle [inference]

spherical high-density lipoprotein particle

triglyceride-rich plasma lipoprotein particle [inference]

chylomicron

cellular anatomical structure [inference]

extracellular region

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
phospholipid binding	IDA
phospholipid binding	IBA
lipid binding	IEA
cholesterol binding	IC

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

lipoprotein particle receptor binding [inference]

high-density lipoprotein particle receptor binding

lipid binding

steroid binding [inference]

sterol binding [inference]

cholesterol binding

phospholipid binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

lipase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

lipase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

apolipoprotein C-III

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 12 in total

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Gene Ontology
high-density lipoprotein particle receptor binding
lipase inhibitor activity
lipid binding
lipid metabolic process
lipid transport
lipoprotein metabolic process
negative regulation of high-density lipoprotein particle clearance
negative regulation of low-density lipoprotein particle clearance
negative regulation of triglyceride catabolic process
negative regulation of very-low-density lipoprotein particle clearance

Displaying **all 2** entries
InterPro
Apolipoprotein CIII superfamily
Apolipoprotein CIII

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:10603	glucose intolerance	Alliance of Genome Resources
DOID:1561	cognitive disorder	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources
DOID:13809	familial combined hyperlipidemia	Alliance of Genome Resources
DOID:784	chronic kidney disease	Alliance of Genome Resources
DOID:0111370	apolipoprotein C-III deficiency	Alliance of Genome Resources
DOID:3145	hyperlipoproteinemia type III	Alliance of Genome Resources

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11814	MGI:88055

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

OrthoDB (Group)

International Collaboration

Acknowledgements