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cellular communication network factor 1

Summary

Gene Symbol

CCN1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3491

KEGG Gene ID

[""]

PubChem

3491

Alliance of Genome Resources

HGNC:2654

Annotation

Keyword

3D-structure
Cell adhesion
Chemotaxis
Disulfide bond
Growth factor binding
Heparin-binding
Phosphoprotein
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O00622	Cellular communication network factor 1 Cysteine-rich angiogenic inducer 61 Insulin-like growth factor-binding protein 10 Protein CYR61 Protein GIG1
Q6FI18	Cellular communication network factor 1 Cysteine-rich angiogenic inducer 61 Protein CYR61

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 33 in total

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GO Term	Evidence Code	PMID
osteoblast differentiation
intussusceptive angiogenesis
atrioventricular valve morphogenesis
apoptotic process involved in heart morphogenesis
ventricular septum development

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion [inference]

chorio-allantoic fusion

signal transduction

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

metabolic process [inference]

reactive oxygen species metabolic process

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

apoptotic process involved in development [inference]

apoptotic process involved in morphogenesis [inference]

apoptotic process involved in heart morphogenesis

cellular developmental process [inference]

cell differentiation [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

developmental process [inference]

anatomical structure morphogenesis [inference]

heart valve morphogenesis [inference]

atrioventricular valve morphogenesis

cardiac septum morphogenesis [inference]

atrial septum morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis [inference]

intussusceptive angiogenesis

anatomical structure development [inference]

blood vessel development [inference]

placenta blood vessel development [inference]

labyrinthine layer blood vessel development

cardiac septum development [inference]

ventricular septum development

animal organ development [inference]

embryonic organ development [inference]

labyrinthine layer blood vessel development

cellular developmental process [inference]

cell differentiation [inference]

locomotion [inference]

taxis [inference]

chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of osteoblast proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation

positive regulation of osteoblast differentiation

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of developmental process

positive regulation of cell differentiation

positive regulation of osteoblast differentiation

positive regulation of cartilage development

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification

positive regulation of bone mineralization

positive regulation of cartilage development

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation

positive regulation of osteoblast differentiation

regulation of osteoblast differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of developmental process

positive regulation of cell differentiation

positive regulation of osteoblast differentiation

positive regulation of cartilage development

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development

regulation of cartilage development [inference]

positive regulation of cartilage development

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

positive regulation of cell-substrate adhesion

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of osteoblast proliferation

regulation of osteoblast proliferation [inference]

positive regulation of osteoblast proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component biogenesis [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation

positive regulation of osteoblast differentiation

regulation of osteoblast differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of osteoblast proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation

positive regulation of osteoblast differentiation

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of ossification

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification

positive regulation of bone mineralization

positive regulation of cartilage development

regulation of multicellular organismal development

regulation of cartilage development [inference]

positive regulation of cartilage development

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	IBA
extracellular region	IEA
obsolete extracellular space
endoplasmic reticulum lumen	TAS
extracellular matrix	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
integrin binding	IBA
integrin binding	IEA
extracellular matrix structural constituent	RCA
protein binding	IPI
heparin binding	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

growth factor binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

extracellular matrix binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ccn

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 2** entries
Gene Ontology
heparin binding
integrin binding

Displaying **all 9** entries
InterPro
CCN, TSP1 domain
Cystine knot, C-terminal
Glycoprotein hormone subunit beta
Growth factor receptor cysteine-rich domain superfamily
IGFBP-related, CNN
Insulin-like growth factor-binding protein, IGFBP
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat
VWFC domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3070	high grade glioma	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements