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acyl-CoA dehydrogenase short chain

Summary

Gene Symbol

ACADS

Aliases

ACAD3
SCAD

Organism

Homo sapiens (human)

External Links

NCBI Gene

HGNC

KEGG Gene ID

["hsa:35"]

PubChem

Alliance of Genome Resources

HGNC:90

JoGo

ACADS

TogoVar

ACADS

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Disease variant
FAD
Fatty acid metabolism
Mitochondrion
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Transit peptide

Proteins

Displaying **all 4** entries
UniProt	Protein Name
E5KSD5	Butyryl-CoA dehydrogenase
E9PE82	Butyryl-CoA dehydrogenase
B4DUH1	Butyryl-CoA dehydrogenase
P16219	Butyryl-CoA dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
fatty acid beta-oxidation	TAS
fatty acid beta-oxidation	IC
fatty acid beta-oxidation using acyl-CoA dehydrogenase	IDA
fatty acid beta-oxidation using acyl-CoA dehydrogenase	IBA
fatty acid beta-oxidation using acyl-CoA dehydrogenase	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

short-chain fatty acid catabolic process [inference]

butyrate catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

short-chain fatty acid catabolic process [inference]

butyrate catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

short-chain fatty acid catabolic process [inference]

butyrate catabolic process

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

short-chain fatty acid metabolic process [inference]

butyrate metabolic process [inference]

butyrate catabolic process

short-chain fatty acid catabolic process [inference]

butyrate catabolic process

lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

short-chain fatty acid catabolic process [inference]

butyrate catabolic process

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

short-chain fatty acid catabolic process [inference]

butyrate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

short-chain fatty acid catabolic process [inference]

butyrate catabolic process

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

short-chain fatty acid metabolic process [inference]

butyrate metabolic process [inference]

butyrate catabolic process

short-chain fatty acid catabolic process [inference]

butyrate catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

short-chain fatty acid catabolic process [inference]

butyrate catabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

short-chain fatty acid catabolic process [inference]

butyrate catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid beta-oxidation using acyl-CoA dehydrogenase

short-chain fatty acid catabolic process [inference]

butyrate catabolic process

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleus	HDA
mitochondrion	IDA
mitochondrion	IBA
mitochondrion	IEA
mitochondrion	HTP

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
acyl-CoA dehydrogenase activity	ISS
acyl-CoA dehydrogenase activity	TAS
acyl-CoA dehydrogenase activity	IDA
acyl-CoA dehydrogenase activity	IMP
acyl-CoA dehydrogenase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-CH group of donors

oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [inference]

acyl-CoA dehydrogenase activity

short-chain fatty acyl-CoA dehydrogenase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Acyl-coa dehydrogenase

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
Gene Ontology
flavin adenine dinucleotide binding
oxidoreductase activity, acting on the CH-CH group of donors
oxidoreductase activity

Displaying **all 8** entries
InterPro
Acyl-CoA dehydrogenase, conserved site
Acyl-CoA dehydrogenase-like, C-terminal
Acyl-CoA dehydrogenase/oxidase, C-terminal
Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
Acyl-CoA dehydrogenase/oxidase, N-terminal
Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
Acyl-CoA oxidase/dehydrogenase, middle domain

Human Protein Atlas

ENSG00000122971

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:24004

H⁺ + butanoyl-CoA

(2E)-butenoyl-CoA

Enzyme

1.3.8.1

PMID

RHEA:47196

H⁺ + a short-chain 2,3-saturated fatty acyl-CoA

a short-chain (2E)-enoyl-CoA

Enzyme

1.3.8.1

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080154	short chain acyl-CoA dehydrogenase deficiency	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 37 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000544	External ophthalmoplegia
HP:0000648	Optic atrophy
HP:0000708	Atypical behavior
HP:0000709	Psychosis
HP:0000750	Delayed speech and language development
HP:0001250	Seizure
HP:0001251	Ataxia
HP:0001252	Hypotonia