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joining chain of multimeric IgA and IgM

Summary

Gene Symbol

JCHAIN

Organism

Homo sapiens (human)

External Links

NCBI Gene

3512

PubChem

3512

Alliance of Genome Resources

HGNC:5713

Annotation

Keyword

3D-structure
Direct protein sequencing
Disulfide bond
Glycoprotein
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P01591	Joining chain of multimeric IgA and IgM

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
adaptive immune response	IDA	21786026
glomerular filtration	IMP	23398317
immune response	NAS	2984306
humoral immune response	IBA
antibacterial humoral response	IDA	23250751

GO Hierarchy

biological process

immune system process [inference]

immune response

adaptive immune response

humoral immune response

antimicrobial humoral response [inference]

antibacterial humoral response

innate immune response

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal filtration [inference]

glomerular filtration

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

innate immune response

immune response

adaptive immune response

humoral immune response

antimicrobial humoral response [inference]

antibacterial humoral response

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of respiratory burst

regulation of respiratory burst [inference]

positive regulation of respiratory burst

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of respiratory burst

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GO Term	Evidence Code	PMID
extracellular region	NAS	14718574 2984306
extracellular region	TAS
extracellular space	IDA	23398317
extracellular space	HDA	16502470 22664934 23580065
extracellular exosome	HDA	19199708 23533145

GO Hierarchy

cellular component

protein-containing complex [inference]

immunoglobulin complex [inference]

immunoglobulin complex, circulating [inference]

IgA immunoglobulin complex, circulating [inference]

monomeric IgA immunoglobulin complex

polymeric IgA immunoglobulin complex [inference]

dimeric IgA immunoglobulin complex

secretory dimeric IgA immunoglobulin complex

secretory IgA immunoglobulin complex

secretory dimeric IgA immunoglobulin complex

IgM immunoglobulin complex, circulating [inference]

IgA immunoglobulin complex [inference]

IgA immunoglobulin complex, circulating [inference]

monomeric IgA immunoglobulin complex

polymeric IgA immunoglobulin complex [inference]

dimeric IgA immunoglobulin complex

secretory dimeric IgA immunoglobulin complex

secretory IgA immunoglobulin complex

secretory dimeric IgA immunoglobulin complex

IgM immunoglobulin complex [inference]

IgM immunoglobulin complex, circulating [inference]

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

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GO Term	Evidence Code	PMID
single-stranded DNA binding	IDA	21786026
antigen binding	NAS	2984306
IgA binding	IMP	17237408
protein-macromolecule adaptor activity	IEA
phosphatidylcholine binding	IDA	21786026

GO Hierarchy

molecular function

binding [inference]

antigen binding

protein binding [inference]

signaling receptor binding [inference]

immunoglobulin receptor binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

phospholipid binding [inference]

phosphatidylcholine binding

ion binding [inference]

cation binding [inference]

phosphatidylcholine binding

protein-containing complex binding [inference]

immunoglobulin binding [inference]

IgA binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

single-stranded DNA binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

peptidoglycan binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Immunoglobulin J chain

Functional Category

L: Replication, recombination and repair
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
humoral immune response
immunoglobulin receptor binding

Displaying 1 entry
InterPro
Immunoglobulin J chain

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	3512	Xenbase:XB-GENE-956584
Mus musculus	16069	RGD:1310155	MOUSE45268
Bos taurus	280821		BOVIN31627
Rattus norvegicus	360922		RATNO07632
Pan troglodytes	461276		PANTR33818
Canis lupus familiaris	475166		CANLF03469
Macaca mulatta	706650		MACMU36260
Pongo abelii	100172285		PONAB28421
Taeniopygia guttata	100217545		TAEGU23767
Meleagris gallopavo	100545573		MELGA09950

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements