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joining chain of multimeric IgA and IgM

Summary

Gene Symbol

JCHAIN

Organism

Homo sapiens (human)

External Links

NCBI Gene

3512

PubChem

3512

Alliance of Genome Resources

HGNC:5713

Annotation

Keyword

3D-structure
Direct protein sequencing
Disulfide bond
Glycoprotein
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P01591	Joining chain of multimeric IgA and IgM

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
adaptive immune response	IDA	21786026
glomerular filtration	IMP	23398317
immune response	NAS	2984306
humoral immune response	IBA
antibacterial humoral response	IDA	23250751

GO Hierarchy

biological process

immune system process [inference]

immune response

adaptive immune response

humoral immune response

antimicrobial humoral response [inference]

antibacterial humoral response

innate immune response

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal filtration [inference]

glomerular filtration

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

innate immune response

immune response

adaptive immune response

humoral immune response

antimicrobial humoral response [inference]

antibacterial humoral response

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of respiratory burst

regulation of respiratory burst [inference]

positive regulation of respiratory burst

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of respiratory burst

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
monomeric IgA immunoglobulin complex	IDA	23250751
dimeric IgA immunoglobulin complex	IMP	17237408
secretory IgA immunoglobulin complex	IDA	23250751 24145934 32029686
secretory dimeric IgA immunoglobulin complex	IDA	24145934
pentameric IgM immunoglobulin complex	IDA	21786026 23250751 24145934 32029689 36949194 37095205

GO Hierarchy

cellular component

protein-containing complex [inference]

immunoglobulin complex [inference]

immunoglobulin complex, circulating [inference]

IgA immunoglobulin complex, circulating [inference]

monomeric IgA immunoglobulin complex

polymeric IgA immunoglobulin complex [inference]

dimeric IgA immunoglobulin complex

secretory dimeric IgA immunoglobulin complex

secretory IgA immunoglobulin complex

secretory dimeric IgA immunoglobulin complex

IgM immunoglobulin complex, circulating [inference]

IgA immunoglobulin complex [inference]

IgA immunoglobulin complex, circulating [inference]

monomeric IgA immunoglobulin complex

polymeric IgA immunoglobulin complex [inference]

dimeric IgA immunoglobulin complex

secretory dimeric IgA immunoglobulin complex

secretory IgA immunoglobulin complex

secretory dimeric IgA immunoglobulin complex

IgM immunoglobulin complex [inference]

IgM immunoglobulin complex, circulating [inference]

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

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GO Term	Evidence Code	PMID
single-stranded DNA binding	IDA	21786026
antigen binding	NAS	2984306
IgA binding	IMP	17237408
protein-macromolecule adaptor activity	IEA
phosphatidylcholine binding	IDA	21786026

GO Hierarchy

molecular function

binding [inference]

antigen binding

protein binding [inference]

signaling receptor binding [inference]

immunoglobulin receptor binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

phospholipid binding [inference]

phosphatidylcholine binding

ion binding [inference]

cation binding [inference]

phosphatidylcholine binding

protein-containing complex binding [inference]

immunoglobulin binding [inference]

IgA binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

single-stranded DNA binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

peptidoglycan binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Immunoglobulin J chain

Functional Category

L: Replication, recombination and repair
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
humoral immune response
immunoglobulin receptor binding

Displaying 1 entry
InterPro
Immunoglobulin J chain

Ortholog

Displaying entries **41 - 50** of 53 in total

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Species	Gene ID	Orthologous MAtrix
Mandrillus leucophaeus	105552470	MANLE33715
Cercocebus atys	105596205	CERAT35958
Aotus nancymaae	105725406	AOTNA29784
Propithecus coquereli	105822834	PROCO17135
Equus asinus asinus	106835097	EQUAS07311
Pseudonaja textilis	113447177	PSETE20524
Athene cunicularia	113479597	ATHCN09466
Bos indicus x Bos taurus	113894358	BOBOX04342
Vombatus ursinus	114037549	VOMUR20256
Podarcis muralis	114604119	PODMU29115