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interleukin 1 receptor type 1

Summary

Gene Symbol

IL1R1

Aliases

CD121A
D2S1473
interleukin-1 receptor, type I

Organism

Homo sapiens (human)

External Links

NCBI Gene

3554

HGNC

5993

PubChem

3554

Alliance of Genome Resources

HGNC:5993

JoGo

IL1R1

TogoVar

IL1R1

Annotation

Keyword

3D-structure
Cell membrane
Disease variant
Disulfide bond
Glycoprotein
Hydrolase
Immunoglobulin domain
Inflammatory response
NAD
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P14778	CD121 antigen-like family member A Interleukin-1 receptor alpha Interleukin-1 receptor type I p80
B8ZZW4	CD121 antigen-like family member A Interleukin-1 receptor alpha Interleukin-1 receptor type I p80

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
microglial cell activation involved in immune response	NAS
inflammatory response
immune response	TAS
signal transduction	IEA
cell surface receptor signaling pathway	TAS

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

immune response

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

glial cell activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

signal transduction

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

interleukin-1-mediated signaling pathway

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

glial cell activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

system process [inference]

muscle system process [inference]

muscle adaptation [inference]

smooth muscle adaptation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

immune response

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

response to interleukin-1

muscle adaptation [inference]

smooth muscle adaptation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

regulation of cellular extravasation [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

regulation of neutrophil extravasation [inference]

positive regulation of neutrophil extravasation

regulation of neutrophil migration [inference]

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

regulation of neutrophil extravasation [inference]

positive regulation of neutrophil extravasation

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T cell cytokine production [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T-helper 1 cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T cell cytokine production [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T-helper 1 cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T cell cytokine production [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T-helper 1 cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T-helper 1 cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

positive regulation of platelet-derived growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

positive regulation of platelet-derived growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

regulation of cellular extravasation [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

regulation of neutrophil extravasation [inference]

positive regulation of neutrophil extravasation

regulation of neutrophil migration [inference]

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

regulation of neutrophil extravasation [inference]

positive regulation of neutrophil extravasation

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

positive regulation of platelet-derived growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

positive regulation of platelet-derived growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

positive regulation of platelet-derived growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

positive regulation of platelet-derived growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

positive regulation of platelet-derived growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T cell cytokine production [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T-helper 1 cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T-helper 1 cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

interleukin-1-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

positive regulation of platelet-derived growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of platelet-derived growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

positive regulation of platelet-derived growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T cell cytokine production [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T-helper 1 cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T cell cytokine production [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T-helper 1 cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T cell cytokine production [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T-helper 1 cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T cell cytokine production [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T-helper 1 cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of interleukin-1-mediated signaling pathway

positive regulation of platelet-derived growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

regulation of cellular extravasation [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

regulation of neutrophil extravasation [inference]

positive regulation of neutrophil extravasation

regulation of neutrophil migration [inference]

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

regulation of neutrophil extravasation [inference]

positive regulation of neutrophil extravasation

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of cellular extravasation [inference]

positive regulation of neutrophil extravasation

positive regulation of neutrophil migration [inference]

positive regulation of neutrophil extravasation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T cell cytokine production [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of T-helper 1 cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of T cell cytokine production [inference]

positive regulation of T-helper 1 cell cytokine production

positive regulation of type II interferon production

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
extracellular region	IPI
extracellular region	IEA
plasma membrane	TAS
plasma membrane	IBA
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
protease binding
transmembrane signaling receptor activity	TAS
cytokine receptor activity	IEA
interleukin-1 receptor activity	TAS
interleukin-1 receptor activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

NAD+ nucleosidase activity, cyclic ADP-ribose generating

binding [inference]

protein binding

signaling receptor binding [inference]

growth factor receptor binding [inference]

platelet-derived growth factor receptor binding

growth factor binding [inference]

interleukin-1 binding

enzyme binding [inference]

protease binding

cytokine binding [inference]

interleukin-1 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

cytokine receptor activity

interleukin-1 receptor activity

interleukin-1, type I, activating receptor activity

immune receptor activity [inference]

cytokine receptor activity

interleukin-1 receptor activity

interleukin-1, type I, activating receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

interleukin-1 receptor type 1

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
cytokine-mediated signaling pathway
hydrolase activity
interleukin-1 binding
interleukin-1 receptor activity
interleukin-1-mediated signaling pathway
regulation of inflammatory response

Displaying **all 9** entries
InterPro
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Interleukin-1 receptor family
Interleukin-1 receptor type 1
Interleukin-1 receptor type I/II
Toll/interleukin-1 receptor homology (TIR) domain superfamily
Toll/interleukin-1 receptor homology (TIR) domain

Rhea

RHEA:16301

H₂O + NAD⁺

H⁺ + nicotinamide + ADP-D-ribose

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060645	chronic recurrent multifocal osteomyelitis	Alliance of Genome Resources
DOID:418	systemic scleroderma	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 6** entries
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0001945	Fever
HP:0002653	Bone pain
HP:0002754	Osteomyelitis
HP:0003565	Elevated erythrocyte sedimentation rate
HP:0100847	Palmoplantar pustulosis