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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

C-X-C motif chemokine receptor 1

Summary

Gene Symbol

CXCR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3577

KEGG Gene ID

PubChem

3577

Alliance of Genome Resources

HGNC:6026

Annotation

Keyword

3D-structure
Cell membrane
Chemotaxis
Disulfide bond
G-protein coupled receptor
Glycoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P25024	CDw128a High affinity interleukin-8 receptor A IL-8 receptor type 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
dendritic cell chemotaxis	TAS
dendritic cell chemotaxis	IEA
chemotaxis	IEA
immune response	IBA
cell surface receptor signaling pathway	IDA

GO Hierarchy

biological process

immune system process [inference]

immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

G protein-coupled receptor signaling pathway

chemokine-mediated signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

calcium-mediated signaling

metabolic process [inference]

respiratory burst

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

locomotion [inference]

taxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

response to stimulus [inference]

immune response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of chemotaxis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of chemotaxis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

G protein-coupled receptor signaling pathway

chemokine-mediated signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

calcium-mediated signaling

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
secretory granule membrane	TAS
secretory granule membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane

bounding membrane of organelle [inference]

secretory granule membrane

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
interleukin-8 receptor activity	IDA
interleukin-8 receptor activity	IEA
G protein-coupled receptor activity	TAS
G protein-coupled receptor activity	IEA
chemokine receptor activity	TAS

GO Hierarchy

molecular function

binding [inference]

protein binding

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

C-X-C chemokine binding [inference]

interleukin-8 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity

interleukin-8 receptor activity

G protein-coupled receptor activity

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity

interleukin-8 receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity

interleukin-8 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:11400	pyelonephritis	Alliance of Genome Resources
DOID:526	human immunodeficiency virus infectious disease	Alliance of Genome Resources
DOID:0080784	urinary tract infection	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	227288	MGI:2448715
Rattus norvegicus	54258	RGD:2905

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026