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MIRAGE
interleukin 12A
Summary
- Gene Symbol
-
- IL12A
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cytokine
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Growth factor
- Host-virus interaction
- Proteomics identification
- Reference proteome
- Secreted
- Signal
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of T cell mediated cytotoxicity |
|
|
| negative regulation of T-helper 1 type immune response |
|
|
| positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target |
|
|
| immune response |
|
|
| immune response |
|
GO Hierarchy
biological process
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte migration [inference]
regulation of leukocyte activation [inference]
regulation of immune effector process [inference]
positive regulation of immune effector process [inference]
regulation of leukocyte mediated immunity [inference]
regulation of immune response [inference]
regulation of adaptive immune response [inference]
regulation of immune response to tumor cell [inference]
regulation of innate immune response [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of cellular process [inference]
positive regulation of response to stimulus [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
regulation of signal transduction [inference]
regulation of response to external stimulus [inference]
positive regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of adaptive immune response [inference]
regulation of immune response to tumor cell [inference]
regulation of innate immune response [inference]
regulation of response to stress [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of cell adhesion [inference]
regulation of cell killing [inference]
regulation of cell population proliferation [inference]
positive regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of cell activation [inference]
regulation of cell motility [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytoplasm |
|
|
| endoplasmic reticulum lumen |
|
|
| cell surface |
|
|
| late endosome lumen |
|
|
| interleukin-12 complex |
|
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytokine activity |
|
|
| cytokine activity |
|
|
| cytokine activity |
|
|
| cytokine activity |
|
|
| interleukin-12 receptor binding |
|
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Interleukin-12 subunit alpha
- Functional Category
-
- G: Carbohydrate transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cytokine activity |
| growth factor activity |
| immune response |
| interleukin-12 receptor binding |
| InterPro |
|---|
| Four-helical cytokine-like, core |
| Interleukin-12 alpha |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:12236 | primary biliary cholangitis | |
| DOID:684 | hepatocellular carcinoma | |
| DOID:1883 | hepatitis C |
Ortholog
| Species | Gene ID | Alliance of Genome Resources |
|---|---|---|
| 16159 | MGI:96539 | |
| 84405 | RGD:620562 |
