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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

integrin subunit alpha L

Summary

Gene Symbol

ITGAL

Organism

Homo sapiens (human)

External Links

NCBI Gene

3683

KEGG Gene ID

PubChem

3683

Alliance of Genome Resources

HGNC:6148

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Host-virus interaction
Integrin
Magnesium
Metal-binding
Phagocytosis
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B2RAL6	CD11 antigen-like family member A Leukocyte adhesion glycoprotein LFA-1 alpha chain Leukocyte function-associated molecule 1 alpha chain
P20701	CD11 antigen-like family member A Leukocyte adhesion glycoprotein LFA-1 alpha chain Leukocyte function-associated molecule 1 alpha chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IMP
phagocytosis
inflammatory response	NAS
cell adhesion	NAS
cell adhesion	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell activation

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte migration [inference]

cellular extravasation [inference]

T cell extravasation [inference]

memory T cell extravasation

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration [inference]

T cell extravasation [inference]

memory T cell extravasation

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell activation

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

cell-substrate adhesion [inference]

cell-matrix adhesion

cell adhesion mediated by integrin

cell-cell adhesion mediated by integrin

cell-cell adhesion

signal transduction

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

cellular extravasation [inference]

T cell extravasation [inference]

memory T cell extravasation

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration [inference]

T cell extravasation [inference]

memory T cell extravasation

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell activation

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

receptor clustering

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

import into cell [inference]

endocytosis [inference]

phagocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

Displaying entries **6 - 10** of 21 in total

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GO Term	Evidence Code	PMID
integrin complex	NAS
integrin complex	TAS
integrin complex	IEA
external side of plasma membrane	IEA
cell surface	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alphaL-beta2 complex

protein complex involved in cell adhesion [inference]

integrin complex

integrin alphaL-beta2 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alphaL-beta2 complex

cellular anatomical structure [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane

specific granule membrane

bounding membrane of organelle [inference]

secretory granule membrane

specific granule membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

anchoring junction [inference]

cell-cell junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cell adhesion receptor activity	IDA
protein binding	IPI
ICAM-3 receptor activity	IMP
signaling receptor activity	IBA
protein-containing complex binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

cell adhesion molecule binding

cell adhesion mediator activity [inference]

cell adhesion receptor activity

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

ICAM-3 receptor activity

cell adhesion receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	16408	MGI:96606

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026