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Guidelines

MIRAGE

integrin subunit alpha V

Summary

Gene Symbol

ITGAV

Organism

Homo sapiens (human)

External Links

NCBI Gene

3685

KEGG Gene ID

PubChem

3685

Alliance of Genome Resources

HGNC:6150

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Integrin
Metal-binding
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
L7RXH0	Vitronectin receptor subunit alpha
P06756	Vitronectin receptor Vitronectin receptor subunit alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 57 in total

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GO Term	Evidence Code	PMID
angiogenesis	IEP
angiogenesis	IBA
angiogenesis	IEA
vasculogenesis	IEA
formation of primary germ layer	IEA

GO Hierarchy

biological process

cellular process [inference]

cell-substrate adhesion

cell adhesion mediated by integrin

cell-cell adhesion

heterotypic cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

signal transduction in absence of ligand [inference]

extrinsic apoptotic signaling pathway in absence of ligand

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

transforming growth factor beta production

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

transforming growth factor beta production

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

cellular developmental process [inference]

cell differentiation [inference]

cell motility [inference]

wound healing, spreading of cells [inference]

wound healing, spreading of epidermal cells

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

multicellular organismal process [inference]

cytokine production [inference]

transforming growth factor beta production

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

anatomical structure development [inference]

tissue development

cellular developmental process [inference]

cell differentiation [inference]

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

symbiont entry into host [inference]

symbiont entry into host cell

entry into host cell by a symbiont-containing vacuole

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

import into cell [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of small GTPase mediated signal transduction

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of intracellular signal transduction

positive regulation of small GTPase mediated signal transduction

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of small GTPase mediated signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport

negative regulation of transport [inference]

negative regulation of lipid transport

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of phagocytosis

regulation of lipid localization [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport

negative regulation of lipid localization [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of entry of bacterium into host cell [inference]

negative regulation of entry of bacterium into host cell

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of small GTPase mediated signal transduction

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of osteoblast proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of small GTPase mediated signal transduction

positive regulation of cell adhesion

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of small GTPase mediated signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of lipoprotein metabolic process

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of lipid storage

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of transport [inference]

negative regulation of lipid transport

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

negative regulation of lipid localization [inference]

negative regulation of entry of bacterium into host cell

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of small GTPase mediated signal transduction

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of intracellular signal transduction

positive regulation of small GTPase mediated signal transduction

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of small GTPase mediated signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

signal transduction in absence of ligand [inference]

extrinsic apoptotic signaling pathway in absence of ligand

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of small GTPase mediated signal transduction

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of intracellular signal transduction

positive regulation of small GTPase mediated signal transduction

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of small GTPase mediated signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of lipid storage [inference]

negative regulation of lipid storage

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of lipoprotein metabolic process

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of lipoprotein metabolic process

regulation of protein metabolic process [inference]

regulation of lipoprotein metabolic process [inference]

negative regulation of lipoprotein metabolic process

negative regulation of protein metabolic process [inference]

negative regulation of lipoprotein metabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of lipoprotein metabolic process [inference]

negative regulation of lipoprotein metabolic process

negative regulation of protein metabolic process [inference]

negative regulation of lipoprotein metabolic process

regulation of cell adhesion [inference]

positive regulation of cell adhesion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of osteoblast proliferation

regulation of osteoblast proliferation [inference]

positive regulation of osteoblast proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of osteoblast proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of small GTPase mediated signal transduction

positive regulation of cell adhesion

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of lipoprotein metabolic process

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of lipid storage

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of phagocytosis

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of lipoprotein particle clearance [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

regulation of low-density lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying entries **6 - 10** of 42 in total

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GO Term	Evidence Code	PMID
focal adhesion	IDA
focal adhesion	IEA
focal adhesion	HDA
integrin complex	NAS
integrin complex	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

protein complex involved in cell adhesion [inference]

integrin complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

cellular anatomical structure [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

specific granule membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

specific granule membrane

plasma membrane region [inference]

cell projection membrane [inference]

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
virus receptor activity
opsonin binding	ISS
opsonin binding	IEA
fibronectin binding	IDA
protease binding	IDA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

integrin binding

growth factor binding [inference]

insulin-like growth factor binding [inference]

insulin-like growth factor I binding

enzyme binding [inference]

protease binding

kinase binding [inference]

protein kinase binding [inference]

protein kinase C binding

cytokine binding [inference]

chemokine binding [inference]

C-X3-C chemokine binding

transforming growth factor beta binding

cell adhesion molecule binding [inference]

integrin binding

exogenous protein binding [inference]

virus receptor activity

extracellular matrix protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

extracellular matrix binding

molecular transducer activity [inference]

signaling receptor activity

coreceptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

integrin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 4** entries
Gene Ontology
cell adhesion mediated by integrin
cell-matrix adhesion
integrin binding
integrin-mediated signaling pathway

Displaying **all 9** entries
InterPro
FG-GAP repeat
Integrin alpha beta-propellor
Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Integrin alpha chain
Integrin alpha, N-terminal
Integrin alpha, first immunoglubulin-like domain
Integrin alpha, second immunoglobulin-like domain
Integrin alpha, third immunoglobulin-like domain
Integrin domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:9119	acute myeloid leukemia	Alliance of Genome Resources
DOID:7693	abdominal aortic aneurysm	Alliance of Genome Resources

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	16410	MGI:96608
Caenorhabditis elegans	176240	WB:WBGene00003929
Drosophila melanogaster	32661	FB:FBgn0001250

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Last updated: April 6, 2026