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Guidelines

MIRAGE

ATP binding cassette subfamily C member 6

Summary

Gene Symbol

ABCC6

Organism

Homo sapiens (human)

External Links

NCBI Gene

368

KEGG Gene ID

PubChem

368

Alliance of Genome Resources

HGNC:57

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Disease variant
Endoplasmic reticulum
Glycoprotein
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Translocase
Transmembrane helix
Transport
Vision

Proteins

Displaying 1 entry
UniProt	Protein Name
O95255	Anthracycline resistance-associated protein Multi-specific organic anion transporter E Multidrug resistance-associated protein 6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
visual perception
response to xenobiotic stimulus	TAS
response to xenobiotic stimulus	IEA
gene expression	IDA
ATP transport	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular phosphate ion homeostasis

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular phosphate ion homeostasis

inorganic ion homeostasis [inference]

phosphate ion homeostasis

intracellular phosphate ion homeostasis

calcium ion homeostasis

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus

response to metal ion [inference]

response to magnesium ion

response to salt [inference]

response to sodium phosphate

localization [inference]

establishment of localization [inference]

transport [inference]

inorganic anion transport [inference]

inorganic diphosphate transport

organic anion transport [inference]

ATP transport

carboxylic acid transport

icosanoid transport [inference]

leukotriene transport

organophosphate ester transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

purine ribonucleotide transport [inference]

ATP transport

adenine nucleotide transport [inference]

ATP transport

organic acid transport [inference]

carboxylic acid transport

icosanoid transport [inference]

leukotriene transport

transmembrane transport

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

purine ribonucleotide transport [inference]

ATP transport

adenine nucleotide transport [inference]

ATP transport

carbohydrate derivative transport [inference]

purine ribonucleotide transport [inference]

ATP transport

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
plasma membrane	IBA
basal plasma membrane	IDA
basal plasma membrane	IEA
membrane	IEA
basolateral plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

plasma membrane region [inference]

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
ATP binding	TAS
ATP binding	IDA
ATP binding	IEA
ABC-type glutathione S-conjugate transporter activity	EXP

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

ABC-type glutathione S-conjugate transporter activity

sulfur compound transmembrane transporter activity [inference]

ABC-type glutathione S-conjugate transporter activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

ABC-type glutathione S-conjugate transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

multidrug resistance-associated

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:2738	pseudoxanthoma elasticum	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:0050644	arterial calcification of infancy	Alliance of Genome Resources

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	27421	MGI:1351634
Rattus norvegicus	81642	RGD:620268
Saccharomyces cerevisiae S288C	850645	SGD:S000003938

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026