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integrin subunit beta 6

Summary

Gene Symbol

ITGB6

Organism

Homo sapiens (human)

External Links

NCBI Gene

3694

KEGG Gene ID

PubChem

3694

Alliance of Genome Resources

HGNC:6161

Annotation

Keyword

3D-structure
Alternative splicing
Amelogenesis imperfecta
Calcium
Cell adhesion
Cell junction
Cell membrane
Disease variant
Disulfide bond
EGF-like domain
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Integrin
Magnesium
Metal-binding
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
P18564
B4E2B8
E9PEE8
A0A087WXP3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
cell morphogenesis
inflammatory response
cell adhesion	TAS
cell-matrix adhesion	NAS
cell-matrix adhesion	IBA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

immunological memory process [inference]

immunological memory formation process [inference]

memory T cell differentiation

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

transforming growth factor beta production

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

transforming growth factor beta production

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

dendritic cell differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

cell motility [inference]

cell migration

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

cytokine production [inference]

transforming growth factor beta production

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

animal organ morphogenesis [inference]

odontogenesis [inference]

odontogenesis of dentin-containing tooth [inference]

amelogenesis

anatomical structure formation involved in morphogenesis [inference]

amelogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

tooth mineralization [inference]

enamel mineralization

tube development [inference]

respiratory tube development [inference]

bronchiole development

lung alveolus development

animal organ development [inference]

respiratory tube development [inference]

bronchiole development

hard palate development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation involved in immune response [inference]

memory T cell differentiation

dendritic cell differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

chemical homeostasis [inference]

lipid homeostasis [inference]

phospholipid homeostasis

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to wounding [inference]

wound healing

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to abiotic stimulus [inference]

response to radiation [inference]

response to ionizing radiation [inference]

cellular response to ionizing radiation

cellular response to radiation [inference]

cellular response to ionizing radiation

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
plasma membrane	EXP
plasma membrane	TAS
plasma membrane	IEA
focal adhesion	IDA
focal adhesion	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alphav-beta6 complex

protein complex involved in cell adhesion [inference]

integrin complex

integrin alphav-beta6 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alphav-beta6 complex

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone [inference]

intercalated disc

cell-substrate junction [inference]

focal adhesion

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
virus receptor activity
integrin binding	IBA
integrin binding	IEA
protein binding	IPI
coreceptor activity	IDA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

exogenous protein binding [inference]

virus receptor activity

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

coreceptor activity

molecular function regulator activity [inference]

molecular function activator activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110064	amelogenesis imperfecta type 1H	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	16420	MGI:96615
Rattus norvegicus	311061	RGD:1303119
Caenorhabditis elegans	175504	WB:WBGene00003930
Drosophila melanogaster	44885	FB:FBgn0004657

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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