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MIRAGE
inositol 1,4,5-trisphosphate receptor type 2
Summary
- Gene Symbol
-
- ITPR2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- ATP-binding
- Alternative splicing
- Calcium channel
- Cytoplasmic vesicle
- Disease variant
- Endoplasmic reticulum
- Ligand-gated ion channel
- Metal-binding
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Transmembrane helix
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| Q14571 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to hypoxia | ||
| signal transduction | ||
| calcium-mediated signaling | ||
| release of sequestered calcium ion into cytosol | ||
| release of sequestered calcium ion into cytosol |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleoplasm |
|
|
| endoplasmic reticulum |
|
|
| endoplasmic reticulum membrane | ||
| endoplasmic reticulum membrane | ||
| endoplasmic reticulum membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | ||
| inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | ||
| calcium ion binding | ||
| ATP binding | ||
| calcium ion transmembrane transporter activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- ryanodine receptor
- Functional Category
-
- K: Transcription
- P: Inorganic ion transport and metabolism
- T: Signal transduction mechanisms
| InterPro |
|---|
| Ryanodine/Inositol 1,4,5-trisphosphate receptor |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060603 | isolated anhidrosis with normal sweat glands | |
| DOID:332 | amyotrophic lateral sclerosis |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 115550273 | GADMO62004 | ||
| 115586671 | SPAAU43220 | ||
| 115604669 | STRHB22136 | ||
| 116442460 | CORMO19293 | ||
| 116817304 | CHEAB14939 | ||
| 117028439 | RHIFE08728 | ||
| 118144170 | CALJA46354 | ||
| 118315934 | SCOMX01066 | ||
| 118901583 | BALMU03338 | ||
| 122224364 | PANLE17955 |
