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MIRAGE
inositol 1,4,5-trisphosphate receptor type 3
Summary
- Gene Symbol
-
- ITPR3
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Calcium channel
- Charcot-Marie-Tooth disease
- Coiled coil
- Cytoplasmic vesicle
- Disease variant
- Disulfide bond
- Endoplasmic reticulum
- Ligand-gated ion channel
- Membrane
- Neurodegeneration
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Transmembrane helix
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| G protein-coupled receptor signaling pathway | ||
| positive regulation of cytosolic calcium ion concentration | ||
| memory | ||
| calcium-mediated signaling | ||
| platelet activation |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytoplasmic side of endoplasmic reticulum membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| calcium-release channel activity | ||
| phosphatidylinositol binding | ||
| inositol 1,3,4,5 tetrakisphosphate binding | ||
| inositol 1,4,5 trisphosphate binding | ||
| inositol 1,4,5 trisphosphate binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- inositol 1,4,5-trisphosphate receptor
- Functional Category
-
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| InterPro |
|---|
| RIH domain |
| Ryanodine/Inositol 1,4,5-trisphosphate receptor |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10595 | Charcot-Marie-Tooth disease | |
| DOID:9744 | type 1 diabetes mellitus |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 100585914 | NOMLE17403 | ||
| 100659666 | LOXAF03048 | ||
| 100707448 | ORENI38728 | ||
| 100729184 | CAVPO08767 | ||
| 100916996 | SARHA01089 | ||
| 100942290 | OTOGA12580 | ||
| 100982024 | PANPA34170 | ||
| 101001272 | PAPAN33404 | ||
| 101048916 | SAIBB05746 | ||
| 101087993 | FELCA10521 |
