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inositol 1,4,5-trisphosphate receptor type 3

Summary

Gene Symbol

ITPR3

Organism

Homo sapiens (human)

External Links

NCBI Gene

3710

PubChem

3710

Alliance of Genome Resources

HGNC:6182

Annotation

Keyword

3D-structure
Calcium channel
Charcot-Marie-Tooth disease
Coiled coil
Cytoplasmic vesicle
Disease variant
Disulfide bond
Endoplasmic reticulum
Ligand-gated ion channel
Membrane
Neurodegeneration
Phosphoprotein
Receptor
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q14573	IP3 receptor isoform 3 Type 3 inositol 1,4,5-trisphosphate receptor
Q59ES2
A6H8K3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	ISS
positive regulation of cytosolic calcium ion concentration	ISS
memory	IEA
calcium-mediated signaling	IEA
platelet activation	IDA	10828023

GO Hierarchy

biological process

cellular process [inference]

cell activation [inference]

platelet activation

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

multicellular organismal process [inference]

cell activation [inference]

platelet activation

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of taste

cognition [inference]

learning or memory [inference]

memory

behavior [inference]

learning or memory [inference]

memory

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion

response to salt [inference]

response to calcium ion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of localization [inference]

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
nuclear outer membrane	ISS
nucleoplasm	IEA
nucleolus	IEA
cytoplasm	ISS
endoplasmic reticulum	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane

plasma membrane

outer membrane [inference]

organelle outer membrane [inference]

nuclear outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

nuclear membrane [inference]

nuclear outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

nuclear outer membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

sarcoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

sarcoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

nucleolus

cell body [inference]

neuronal cell body

apical part of cell

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane

cluster of actin-based cell projections [inference]

brush border

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
inositol hexakisphosphate binding	ISS
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	ISS
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IDA	10828023 30013099 37898605
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IBA
calcium ion binding	IDA	37898605

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding

small molecule binding [inference]

alcohol binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

inositol hexakisphosphate binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

inositol 1,4,5-trisphosphate receptor

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
calcium channel activity
calcium ion transmembrane transport
calcium ion transport
calcium-mediated signaling
inositol 1,4,5 trisphosphate binding
monoatomic ion channel activity
monoatomic ion transport
release of sequestered calcium ion into cytosol

Displaying **all 2** entries
InterPro
RIH domain
Ryanodine/Inositol 1,4,5-trisphosphate receptor

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10595	Charcot-Marie-Tooth disease	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **71 - 74** of 74 in total

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Species	Gene ID	Orthologous MAtrix
Balaenoptera musculus	118903133	BALMU25850
Panthera leo	122219786	PANLE15961
Ursus americanus	123790908	URSAM01522
Astyanax mexicanus	125806068	ASTMX08862

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OrthoDB (Group)

International Collaboration

Acknowledgements