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lysyl-tRNA synthetase 1

Summary

Gene Symbol

KARS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3735

KEGG Gene ID

PubChem

3735

Alliance of Genome Resources

HGNC:6215

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
Cell membrane
Charcot-Marie-Tooth disease
Cytoplasm
Direct protein sequencing
Disease variant
Host-virus interaction
Intellectual disability
Mitochondrion
Neurodegeneration
Non-syndromic deafness
Nucleus
Phosphoprotein
Protein biosynthesis
Proteomics identification
Reference proteome
Secreted
Transferase

Proteins

Displaying 1 entry
UniProt	Protein Name
Q15046	Lysyl-tRNA synthetase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
basophil activation involved in immune response	IGI
basophil activation involved in immune response	IBA
basophil activation involved in immune response	IEA
positive regulation of inflammatory response to antigenic stimulus	IDA
tRNA aminoacylation for protein translation	NAS

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

basophil activation [inference]

basophil activation involved in immune response

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

basophil activation [inference]

basophil activation involved in immune response

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide biosynthetic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

diadenosine polyphosphate metabolic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide biosynthetic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

diadenosine polyphosphate metabolic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

lysyl-tRNA aminoacylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide biosynthetic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

diadenosine polyphosphate metabolic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

lysyl-tRNA aminoacylation

RNA processing [inference]

tRNA processing

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

lysyl-tRNA aminoacylation

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide biosynthetic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

diadenosine polyphosphate metabolic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

diadenosine polyphosphate biosynthetic process [inference]

diadenosine tetraphosphate biosynthetic process

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

basophil activation [inference]

basophil activation involved in immune response

leukocyte activation involved in immune response [inference]

basophil activation involved in immune response

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to ionizing radiation [inference]

response to X-ray

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of immune response [inference]

positive regulation of inflammatory response to antigenic stimulus

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation

regulation of immune response [inference]

regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of inflammatory response to antigenic stimulus

positive regulation of immune response [inference]

positive regulation of inflammatory response to antigenic stimulus

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of immune response [inference]

positive regulation of inflammatory response to antigenic stimulus

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to antigenic stimulus

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to antigenic stimulus

positive regulation of immune response [inference]

positive regulation of inflammatory response to antigenic stimulus

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to antigenic stimulus

regulation of inflammatory response [inference]

regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of inflammatory response to antigenic stimulus

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to antigenic stimulus

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to antigenic stimulus

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to antigenic stimulus

positive regulation of immune response [inference]

positive regulation of inflammatory response to antigenic stimulus

regulation of immune response [inference]

regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of inflammatory response to antigenic stimulus

positive regulation of immune response [inference]

positive regulation of inflammatory response to antigenic stimulus

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to antigenic stimulus

regulation of inflammatory response [inference]

regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of inflammatory response to antigenic stimulus

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to antigenic stimulus

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
extracellular region	IDA
extracellular region	IEA
obsolete extracellular space
nucleus	EXP
nucleus	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

aminoacyl-tRNA synthetase multienzyme complex

catalytic complex [inference]

aminoacyl-tRNA synthetase multienzyme complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
tRNA binding	NAS
tRNA binding	IBA
tRNA binding	IEA
nucleotide binding	IEA
nucleic acid binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

adenylyltransferase activity [inference]

ATP:ADP adenylyltransferase activity

ligase activity [inference]

ligase activity, forming carbon-oxygen bonds [inference]

aminoacyl-tRNA ligase activity

lysine-tRNA ligase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

aminoacyl-tRNA ligase activity

lysine-tRNA ligase activity

binding [inference]

nucleic acid binding

RNA binding [inference]

tRNA binding

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

scaffold protein binding

amino acid binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

LYSINE--TRNA LIGASE

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
ATP adenylyltransferase activity
ATP binding
diadenosine tetraphosphate biosynthetic process
lysine-tRNA ligase activity
lysyl-tRNA aminoacylation
nucleotide binding
positive regulation of macrophage activation
tRNA aminoacylation for protein translation

Displaying **all 9** entries
InterPro
Aminoacyl-tRNA synthetase, class II (D/K/N)
Aminoacyl-tRNA synthetase, class II
Bacterial/eukaryotic lysine-tRNA ligase, class II
Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
Lysine-tRNA ligase, class II, N-terminal
Lysine-tRNA ligase, class II
Lysyl-tRNA synthetase, class II, C-terminal
Nucleic acid-binding, OB-fold
OB-fold nucleic acid binding domain, AA-tRNA synthetase-type

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110204	Charcot-Marie-Tooth disease recessive intermediate B	Alliance of Genome Resources
DOID:0110534	autosomal recessive nonsyndromic deafness 89	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements