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aconitase 2

Summary

Gene Symbol

ACO2

Organism

Gallus gallus (chicken)

External Links

NCBI Gene: 374009
KEGG Gene ID: gga:374009
PubChem: 374009

Annotation

Keyword

4Fe-4S
Lyase
Mitochondrion
Proteomics identification
Reference proteome
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q5ZMW1
Q8AYI3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
tricarboxylic acid cycle	TAS	https://reactome.org/content/detail/R-GGA-372987
tricarboxylic acid cycle	IBA	http://purl.obolibrary.org/obo/go/references/0000033
tricarboxylic acid cycle	IEA	22301074 30032202 http://purl.obolibrary.org/obo/go/references/0000002 http://purl.obolibrary.org/obo/go/references/0000041 http://purl.obolibrary.org/obo/go/references/0000107
citrate metabolic process

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

primary metabolic process [inference]

tricarboxylic acid cycle

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

citrate metabolic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrion	IBA	http://purl.obolibrary.org/obo/go/references/0000033
mitochondrion	IEA	30032202 http://purl.obolibrary.org/obo/go/references/0000044 http://purl.obolibrary.org/obo/go/references/0000107
mitochondrial matrix	TAS	https://reactome.org/content/detail/R-GGA-373015 https://reactome.org/content/detail/R-GGA-373140
mitochondrial matrix	IEA	http://purl.obolibrary.org/obo/go/references/0000107
cytosol	IBA	http://purl.obolibrary.org/obo/go/references/0000033

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
aconitate hydratase activity	TAS	https://reactome.org/content/detail/R-GGA-373015 https://reactome.org/content/detail/R-GGA-373140
aconitate hydratase activity	IBA	http://purl.obolibrary.org/obo/go/references/0000033
aconitate hydratase activity	IEA	22301074 30032202 http://purl.obolibrary.org/obo/go/references/0000002 http://purl.obolibrary.org/obo/go/references/0000003 http://purl.obolibrary.org/obo/go/references/0000107 http://purl.obolibrary.org/obo/go/references/0000116
iron ion binding	IEA	http://purl.obolibrary.org/obo/go/references/0000107
metal ion binding	IEA	http://purl.obolibrary.org/obo/go/references/0000104

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

aconitate hydratase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

iron ion binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

4 iron, 4 sulfur cluster binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Aconitate hydratase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
4 iron, 4 sulfur cluster binding
iron-sulfur cluster binding
lyase activity
metal ion binding
tricarboxylic acid cycle

Displaying **all 8** entries
InterPro
Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
Aconitase family, 4Fe-4S cluster binding site
Aconitase, domain 2
Aconitase, iron-sulfur domain
Aconitase, mitochondrial-like
Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
Aconitase/3-isopropylmalate dehydratase, swivel