GlyCosmos Portal

Annotation

Keyword

3D-structure
Acetylation
Acyltransferase
Alternative splicing
Direct protein sequencing
Disease variant
Fatty acid metabolism
Metal-binding
Mitochondrion
Potassium
Proteomics identification
Reference proteome
Transit peptide

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A0A5F9ZHL1	Acetoacetyl-CoA thiolase
A0A5F9ZHJ0	Acetoacetyl-CoA thiolase
A0A140VJX1	Acetoacetyl-CoA thiolase
A0A5F9ZI66	Acetoacetyl-CoA thiolase
P24752	Acetoacetyl-CoA thiolase T2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
liver development	IEA
acetyl-CoA biosynthetic process	IDA
L-isoleucine catabolic process	TAS
L-isoleucine catabolic process	IMP
fatty acid beta-oxidation	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

generation of precursor metabolites and energy [inference]

ketone body metabolic process

ketone body catabolic process

sulfur compound metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

propionyl-CoA metabolic process [inference]

propionyl-CoA biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

coenzyme A metabolic process

coenzyme A biosynthetic process

sulfur compound biosynthetic process [inference]

coenzyme A biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

sulfur compound catabolic process [inference]

acetyl-CoA catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

propionyl-CoA metabolic process [inference]

propionyl-CoA biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

coenzyme A metabolic process

coenzyme A biosynthetic process

nucleoside phosphate catabolic process [inference]

acetyl-CoA catabolic process

nucleoside phosphate biosynthetic process [inference]

coenzyme A biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

propionyl-CoA metabolic process [inference]

propionyl-CoA biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

coenzyme A metabolic process

coenzyme A biosynthetic process

nucleoside phosphate catabolic process [inference]

acetyl-CoA catabolic process

nucleoside phosphate biosynthetic process [inference]

coenzyme A biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

acetyl-CoA catabolic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

coenzyme A biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

L-isoleucine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-isoleucine catabolic process

lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid derivative catabolic process [inference]

ketone body catabolic process

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

acetyl-CoA catabolic process

sulfur compound catabolic process [inference]

acetyl-CoA catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

L-isoleucine catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

proteinogenic amino acid catabolic process [inference]

L-isoleucine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-isoleucine catabolic process

ketone body catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

acetyl-CoA catabolic process

purine-containing compound catabolic process [inference]

acetyl-CoA catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

coenzyme A biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

sulfur compound biosynthetic process [inference]

coenzyme A biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

purine-containing compound biosynthetic process [inference]

coenzyme A biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

coenzyme A biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

coenzyme A biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

acetyl-CoA catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

propionyl-CoA metabolic process [inference]

propionyl-CoA biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

coenzyme A metabolic process

coenzyme A biosynthetic process

nucleoside phosphate catabolic process [inference]

acetyl-CoA catabolic process

nucleoside phosphate biosynthetic process [inference]

coenzyme A biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

L-isoleucine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-isoleucine catabolic process

branched-chain amino acid metabolic process [inference]

isoleucine metabolic process [inference]

L-isoleucine catabolic process

branched-chain amino acid catabolic process [inference]

L-isoleucine catabolic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-isoleucine catabolic process

alpha-amino acid metabolic process [inference]

isoleucine metabolic process [inference]

L-isoleucine catabolic process

L-amino acid metabolic process [inference]

L-amino acid catabolic process [inference]

L-isoleucine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-isoleucine catabolic process

lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid oxidation [inference]

fatty acid beta-oxidation

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid derivative catabolic process [inference]

ketone body catabolic process

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

fatty acid derivative metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

propionyl-CoA metabolic process [inference]

propionyl-CoA biosynthetic process

fatty acid derivative catabolic process [inference]

ketone body catabolic process

fatty acid derivative biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

ketone body metabolic process

ketone body catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

L-isoleucine catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

proteinogenic amino acid catabolic process [inference]

L-isoleucine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-isoleucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

branched-chain amino acid metabolic process [inference]

isoleucine metabolic process [inference]

L-isoleucine catabolic process

branched-chain amino acid catabolic process [inference]

L-isoleucine catabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid oxidation [inference]

fatty acid beta-oxidation

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

carboxylic acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

L-isoleucine catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

proteinogenic amino acid catabolic process [inference]

L-isoleucine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-isoleucine catabolic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-isoleucine catabolic process

alpha-amino acid metabolic process [inference]

isoleucine metabolic process [inference]

L-isoleucine catabolic process

L-amino acid metabolic process [inference]

L-amino acid catabolic process [inference]

L-isoleucine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-isoleucine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

L-isoleucine catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

proteinogenic amino acid catabolic process [inference]

L-isoleucine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-isoleucine catabolic process

ketone body catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

propionyl-CoA metabolic process [inference]

propionyl-CoA biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

coenzyme A metabolic process

coenzyme A biosynthetic process

nucleoside phosphate catabolic process [inference]

acetyl-CoA catabolic process

nucleoside phosphate biosynthetic process [inference]

coenzyme A biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

ketone body metabolic process

ketone body catabolic process

purine-containing compound metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

propionyl-CoA metabolic process [inference]

propionyl-CoA biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

coenzyme A metabolic process

coenzyme A biosynthetic process

purine-containing compound biosynthetic process [inference]

coenzyme A biosynthetic process

acyl-CoA biosynthetic process [inference]

acetyl-CoA biosynthetic process

fatty-acyl-CoA biosynthetic process [inference]

propionyl-CoA biosynthetic process

purine-containing compound catabolic process [inference]

acetyl-CoA catabolic process

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

renal tubule development [inference]

nephron tubule development [inference]

proximal convoluted tubule development [inference]

metanephric proximal convoluted tubule development

metanephric nephron tubule development [inference]

metanephric proximal convoluted tubule development

kidney epithelium development [inference]

nephron epithelium development [inference]

nephron tubule development [inference]

proximal convoluted tubule development [inference]

metanephric proximal convoluted tubule development

metanephric nephron tubule development [inference]

metanephric proximal convoluted tubule development

metanephric nephron epithelium development [inference]

metanephric nephron tubule development [inference]

metanephric proximal convoluted tubule development

metanephric epithelium development [inference]

metanephric tubule development [inference]

metanephric nephron tubule development [inference]

metanephric proximal convoluted tubule development

metanephric nephron epithelium development [inference]

metanephric nephron tubule development [inference]

metanephric proximal convoluted tubule development

connective tissue development [inference]

adipose tissue development

tube development [inference]

renal tubule development [inference]

nephron tubule development [inference]

proximal convoluted tubule development [inference]

metanephric proximal convoluted tubule development

metanephric nephron tubule development [inference]

metanephric proximal convoluted tubule development

metanephric tubule development [inference]

metanephric nephron tubule development [inference]

metanephric proximal convoluted tubule development

animal organ development [inference]

gland development [inference]

liver development

response to stimulus [inference]

response to stress [inference]

response to starvation

response to endogenous stimulus [inference]

response to hormone

response to nutrient levels [inference]

response to starvation

response to chemical [inference]

response to hormone

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
mitochondrion	IDA
mitochondrion	IBA
mitochondrion	IEA
mitochondrion	HTP
mitochondrial matrix	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
acetyl-CoA C-acetyltransferase activity	EXP
acetyl-CoA C-acetyltransferase activity	TAS
acetyl-CoA C-acetyltransferase activity	IDA
acetyl-CoA C-acetyltransferase activity	IMP
acetyl-CoA C-acetyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity

acyltransferase activity, transferring groups other than amino-acyl groups

O-acyltransferase activity [inference]

sterol O-acyltransferase activity [inference]

cholesterol O-acyltransferase activity

acetyltransferase activity [inference]

C-acetyltransferase activity

acetyl-CoA C-acetyltransferase activity

C-acyltransferase activity [inference]

acetyl-CoA C-acyltransferase activity [inference]

acetyl-CoA C-acetyltransferase activity

C-acetyltransferase activity

acetyl-CoA C-acetyltransferase activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

coenzyme A binding

cation binding [inference]

metal ion binding

alkali metal ion binding [inference]

potassium ion binding

heterocyclic compound binding [inference]

coenzyme A binding

nucleoside phosphate binding [inference]

coenzyme A binding

sulfur compound binding [inference]

coenzyme A binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

acetyl-CoA acetyltransferase

Functional Category

I: Lipid transport and metabolism
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 3** entries
Gene Ontology
acyltransferase activity, transferring groups other than amino-acyl groups
fatty acid beta-oxidation
transferase activity

Displaying **all 7** entries
InterPro
Thiolase, C-terminal
Thiolase, N-terminal
Thiolase, active site
Thiolase, acyl-enzyme intermediate active site
Thiolase, conserved site
Thiolase-like
Thiolase

Human Protein Atlas

ENSG00000075239

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:21036

acetyl-CoA

acetoacetyl-CoA + CoA

Enzyme

2.3.1.9

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:2978	carbohydrate metabolic disorder	Alliance of Genome Resources
DOID:14723	beta-ketothiolase deficiency	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 44 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000713	Agitation
HP:0000741	Apathy
HP:0000822	Hypertension
HP:0000969	Edema
HP:0000980	Pallor
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0001251	Ataxia
HP:0001252	Hypotonia