GlyCosmos Portal

GlyTouCan

Glycan Structure Repository

GlyComb

Glycoconjugate Repository

GlycoPOST

Glycomics MS raw data Repository

UniCarb-DR

Glycomics MS Repository for glycan annotations from GlycoWorkbench

LM-GlycoRepo

Repository for lectin-assisted multimodality data

All Resources

Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms

Other Information

Release Statistics Download

Tools

Glycan Converters

LM-GlycomeAtlas

Search Tools

Cross Search Glycan Search Publication Search Programmatic Access

Guidelines

MIRAGE

Peptidoglycan recognition protein LA

Summary

Gene Symbol

PGRP-LA

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

39062

KEGG Gene ID

PubChem

39062

Alliance of Genome Resources

FB:FBgn0035975

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Innate immunity
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
M9PEM5
Q95T64

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
immune response	ISS
immune response	IBA
peptidoglycan catabolic process	IMR
peptidoglycan catabolic process	IKR
response to bacterium	IDA

GO Hierarchy

biological process

immune system process [inference]

immune response

innate immune response

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of peptidoglycan recognition protein signaling pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	IBA
plasma membrane	NAS
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
zinc ion binding	IEA
N-acetylmuramoyl-L-alanine amidase activity	IKR
N-acetylmuramoyl-L-alanine amidase activity	IMR
peptidoglycan binding	IKR
peptidoglycan binding	IMR

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

N-acetylmuramoyl-L-alanine amidase activity

peptidoglycan muralytic activity [inference]

N-acetylmuramoyl-L-alanine amidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

peptidoglycan binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peptidoglycan recognition protein

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
P: Inorganic ion transport and metabolism

Displaying **all 3** entries
Gene Ontology
N-acetylmuramoyl-L-alanine amidase activity
peptidoglycan binding
zinc ion binding

Displaying **all 4** entries
InterPro
N-acetylmuramoyl-L-alanine amidase domain
N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily
Peptidoglycan recognition protein family domain, metazoa/bacteria
Peptidoglycan recognition protein

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
membrane	FB:FBrf0231198

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	57757	MGI:1928099
Homo sapiens	114770	HGNC:30013

About Release Notes Help Feedback

Click here to visit the beta site.

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

Logo License Policies Site Map

Contact: [email protected]

GlyCosmos Portal v4.5.0

Last updated: April 6, 2026