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laminin subunit alpha 2

Summary

Gene Symbol

LAMA2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3908

KEGG Gene ID

PubChem

3908

Alliance of Genome Resources

HGNC:6482

Annotation

Keyword

3D-structure
Basement membrane
Cell adhesion
Coiled coil
Congenital muscular dystrophy
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Laminin EGF-like domain
Limb-girdle muscular dystrophy
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P24043	Laminin M chain Laminin-12 subunit alpha Laminin-2 subunit alpha Laminin-4 subunit alpha Merosin heavy chain
Q59H37
A0A087WYF1	Laminin M chain Laminin-12 subunit alpha Laminin-2 subunit alpha Laminin-4 subunit alpha Merosin heavy chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
cell adhesion	IEA
signal transduction	IBA
nervous system development	IBA
axon guidance
muscle organ development	TAS

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

Schwann cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

animal gross anatomical part developmental process [inference]

nervous system development

animal organ development [inference]

muscle organ development

muscle structure development [inference]

muscle organ development

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

Schwann cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, cholinergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic [inference]

positive regulation of synaptic transmission, cholinergic

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, cholinergic

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, cholinergic

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, cholinergic

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cell adhesion

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of multicellular organismal development [inference]

regulation of embryonic development

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, cholinergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic [inference]

positive regulation of synaptic transmission, cholinergic

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, cholinergic

regulation of cell adhesion

positive regulation of cell adhesion

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of synaptic transmission [inference]

positive regulation of synaptic transmission, cholinergic

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cell adhesion

regulation of cellular component organization [inference]

regulation of extracellular matrix organization [inference]

regulation of basement membrane organization

regulation of cell motility [inference]

regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of embryonic development

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IEA
basement membrane	NAS
basement membrane	TAS
basement membrane	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein complex involved in cell adhesion [inference]

protein complex involved in cell-matrix adhesion

extracellular protein-containing complex [inference]

laminin trimer [inference]

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

sarcolemma

cell junction [inference]

synapse

neuromuscular junction

external encapsulating structure [inference]

extracellular matrix

basement membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

synaptic cleft

postsynapse [inference]

dendritic spine

Displaying **all 3** entries
GO Term	Evidence Code	PMID
signaling receptor binding	IEA
structural molecule activity	TAS
extracellular matrix structural constituent	RCA

GO Hierarchy

molecular function

structural molecule activity

extracellular matrix structural constituent

binding [inference]

protein binding [inference]

signaling receptor binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0110274	autosomal recessive limb-girdle muscular dystrophy	Alliance of Genome Resources
DOID:9884	muscular dystrophy	Alliance of Genome Resources
DOID:11830	myopia	Alliance of Genome Resources
DOID:0110636	congenital merosin-deficient muscular dystrophy 1A	Alliance of Genome Resources