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laminin subunit beta 2

Summary

Gene Symbol

LAMB2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3913

KEGG Gene ID

PubChem

3913

Alliance of Genome Resources

HGNC:6487

Annotation

Keyword

Basement membrane
Cell adhesion
Coiled coil
Disease variant
Disulfide bond
Glycoprotein
Laminin EGF-like domain
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P55268	Laminin B1s chain Laminin-11 subunit beta Laminin-14 subunit beta Laminin-15 subunit beta Laminin-3 subunit beta Laminin-4 subunit beta Laminin-7 subunit beta Laminin-9 subunit beta S-laminin subunit beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
cell adhesion
axon guidance
neuromuscular junction development
visual perception
astrocyte development

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

substrate adhesion-dependent cell spreading

cell growth [inference]

developmental cell growth [inference]

sprouting of injured axon [inference]

axon extension involved in regeneration

neuron projection extension [inference]

axon extension [inference]

axon extension involved in regeneration

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

radial glial cell differentiation

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development [inference]

metanephric podocyte development

metanephric glomerular epithelial cell development [inference]

metanephric podocyte development

glial cell development [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

extracellular structure organization [inference]

extracellular matrix organization [inference]

glomerular basement membrane development [inference]

metanephric glomerular basement membrane development

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

glomerular basement membrane development [inference]

metanephric glomerular basement membrane development

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

developmental process [inference]

anatomical structure development [inference]

glomerular basement membrane development [inference]

metanephric glomerular basement membrane development

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development [inference]

metanephric podocyte development

metanephric glomerular epithelial cell development [inference]

metanephric podocyte development

glial cell development [inference]

retina development in camera-type eye

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

radial glial cell differentiation

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development [inference]

metanephric podocyte development

metanephric glomerular epithelial cell development [inference]

metanephric podocyte development

glial cell development [inference]

growth [inference]

cell growth [inference]

developmental cell growth [inference]

sprouting of injured axon [inference]

axon extension involved in regeneration

neuron projection extension [inference]

axon extension [inference]

axon extension involved in regeneration

developmental growth [inference]

developmental cell growth [inference]

sprouting of injured axon [inference]

axon extension involved in regeneration

neuron projection extension [inference]

axon extension [inference]

axon extension involved in regeneration

developmental growth involved in morphogenesis [inference]

sprouting of injured axon [inference]

axon extension involved in regeneration

neuron projection extension [inference]

axon extension [inference]

axon extension involved in regeneration

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cell adhesion

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of cell adhesion [inference]

positive regulation of cell adhesion

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cell adhesion

regulation of cellular component organization [inference]

regulation of extracellular matrix organization [inference]

regulation of basement membrane organization

Displaying entries **16 - 20** of 28 in total

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GO Term	Evidence Code	PMID
extracellular matrix	HDA
neuromuscular junction	IEA
synaptic cleft	IEA
laminin trimer	IEA
laminin-421 trimer	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

protein complex involved in cell adhesion [inference]

protein complex involved in cell-matrix adhesion

extracellular protein-containing complex [inference]

laminin trimer

cellular anatomical structure [inference]

extracellular region

cell junction [inference]

synapse

neuromuscular junction

external encapsulating structure [inference]

extracellular matrix

basement membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

synaptic cleft

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
integrin binding	IEA
structural molecule activity	NAS
extracellular matrix structural constituent	RCA
extracellular matrix structural constituent	ISS
extracellular matrix structural constituent	IBA

GO Hierarchy

molecular function

structural molecule activity

extracellular matrix structural constituent

structural constituent of synapse-associated extracellular matrix

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Laminin

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
animal organ morphogenesis
basement membrane assembly
cell migration
substrate adhesion-dependent cell spreading
tissue development

Displaying **all 2** entries
InterPro
Laminin, N-terminal
Laminin-type EGF domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:1070	primary open angle glaucoma	Alliance of Genome Resources
DOID:0060852	Pierson syndrome	Alliance of Genome Resources
DOID:0080380	nephrotic syndrome type 5	Alliance of Genome Resources