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Guidelines

MIRAGE

lysosome associated membrane protein 2

Summary

Gene Symbol

LAMP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3920

KEGG Gene ID

PubChem

3920

Alliance of Genome Resources

HGNC:6501

Annotation

Keyword

3D-structure
Alternative splicing
Autophagy
Cell membrane
Cytoplasmic vesicle
Direct protein sequencing
Disease variant
Disulfide bond
Endosome
Glycogen storage disease
Glycoprotein
Lysosome
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P13473	CD107 antigen-like family member B LGP-96

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
protein targeting	ISS
protein targeting	IEA
autophagy	IEA
lysosomal lumen acidification	IDA
lysosomal lumen acidification	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

chaperone-mediated autophagy

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

protein metabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

chaperone-mediated autophagy

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

vacuolar transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

lysosomal transport [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

process utilizing autophagic mechanism [inference]

chaperone-mediated autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

homeostatic process [inference]

cellular homeostasis [inference]

muscle cell cellular homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein import

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein localization to lysosome [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of localization [inference]

transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein import

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

vacuolar transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

lysosomal transport [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of protein localization [inference]

protein targeting

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein import

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

vacuolar transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

lysosomal transport [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

vacuolar transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to vacuole involved in autophagy [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

lysosomal transport [inference]

protein targeting to lysosome [inference]

protein targeting to lysosome involved in chaperone-mediated autophagy

biological regulation [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of ferroptosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

negative regulation of NLRP3 inflammasome complex assembly

regulation of cellular process [inference]

regulation of programmed cell death [inference]

positive regulation of programmed cell death [inference]

positive regulation of ferroptosis

regulation of ferroptosis [inference]

positive regulation of ferroptosis

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly

negative regulation of NLRP3 inflammasome complex assembly

regulation of NLRP3 inflammasome complex assembly [inference]

negative regulation of NLRP3 inflammasome complex assembly

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of ferroptosis

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

negative regulation of NLRP3 inflammasome complex assembly

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly

negative regulation of NLRP3 inflammasome complex assembly

regulation of NLRP3 inflammasome complex assembly [inference]

negative regulation of NLRP3 inflammasome complex assembly

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

negative regulation of NLRP3 inflammasome complex assembly

regulation of biological quality [inference]

regulation of protein stability

protein stabilization

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

Displaying entries **1 - 5** of 40 in total

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GO Term	Evidence Code	PMID
autophagosome membrane	IBA
autophagosome membrane	IEA
extracellular region	IDA
obsolete extracellular space
lysosome	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

chaperone-mediated autophagy translocation complex

cellular anatomical structure [inference]

extracellular region

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

late endosome membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

secretory granule membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

autophagosome membrane

lytic vacuole membrane [inference]

lysosomal membrane

azurophil granule membrane

endosome membrane

late endosome membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

secretory granule membrane [inference]

membrane microdomain

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

late endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

secondary lysosome [inference]

autolysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

late endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

secondary lysosome [inference]

autolysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

late endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
protein-macromolecule adaptor activity	IDA
protein-macromolecule adaptor activity	IEA
signaling adaptor activity	IDA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

signaling adaptor activity

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity

ion channel regulator activity [inference]

ion channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Lysosome-associated membrane glycoprotein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
establishment of protein localization to organelle

Displaying **all 3** entries
InterPro
Lysosome-associated membrane glycoprotein 2-like, luminal domains
Lysosome-associated membrane glycoprotein 2-like, transmembrane domain
Lysosome-associated membrane glycoprotein

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050437	Danon disease	Alliance of Genome Resources
DOID:11984	hypertrophic cardiomyopathy	Alliance of Genome Resources

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	16784	MGI:96748
Rattus norvegicus	24944	RGD:2990
Caenorhabditis elegans	180912	WB:WBGene00003053

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Last updated: April 6, 2026