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Aldo-keto reductase 1B

Summary

Gene Symbol

Akr1B

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

39304

KEGG Gene ID

PubChem

39304

Alliance of Genome Resources

FB:FBgn0086254

Annotation

Keyword

Alternative splicing
Cytoplasm
NADP
Oxidoreductase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
M9PF61	Aldose reductase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
D-sorbitol biosynthetic process	IGI
prostaglandin metabolic process	IEA
D-glucuronate catabolic process to D-xylulose 5-phosphate	ISS
retinol metabolic process	IEA
polyol biosynthetic process	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

D-xylulose 5-phosphate metabolic process [inference]

D-glucuronate catabolic process to D-xylulose 5-phosphate

organophosphate metabolic process [inference]

D-xylulose 5-phosphate metabolic process [inference]

D-glucuronate catabolic process to D-xylulose 5-phosphate

catabolic process [inference]

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

D-glucuronate catabolic process [inference]

D-glucuronate catabolic process to D-xylulose 5-phosphate

biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

D-sorbitol biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

D-sorbitol biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

hormone metabolic process [inference]

retinol metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

hexitol metabolic process [inference]

D-sorbitol metabolic process [inference]

D-sorbitol biosynthetic process

hexitol biosynthetic process [inference]

D-sorbitol biosynthetic process

carbohydrate biosynthetic process [inference]

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

D-sorbitol biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

alcohol metabolic process [inference]

polyol metabolic process [inference]

hexitol metabolic process [inference]

D-sorbitol metabolic process [inference]

D-sorbitol biosynthetic process

hexitol biosynthetic process [inference]

D-sorbitol biosynthetic process

polyol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

D-sorbitol biosynthetic process

primary alcohol metabolic process [inference]

retinol metabolic process

alcohol biosynthetic process [inference]

polyol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

D-sorbitol biosynthetic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

D-glucuronate catabolic process [inference]

D-glucuronate catabolic process to D-xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

D-glucuronate catabolic process [inference]

D-glucuronate catabolic process to D-xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

D-glucuronate catabolic process [inference]

D-glucuronate catabolic process to D-xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

D-glucuronate catabolic process [inference]

D-glucuronate catabolic process to D-xylulose 5-phosphate

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

D-glucuronate catabolic process [inference]

D-glucuronate catabolic process to D-xylulose 5-phosphate

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

D-sorbitol biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

olefinic compound metabolic process [inference]

retinol metabolic process

carbohydrate derivative metabolic process [inference]

D-xylulose 5-phosphate metabolic process [inference]

D-glucuronate catabolic process to D-xylulose 5-phosphate

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular region	IDA
obsolete extracellular space
nucleoplasm	HDA
cytoplasm	IEA
mitochondrion	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
aldose reductase (NADPH) activity	ISS
aldose reductase (NADPH) activity	IDA
aldose reductase (NADPH) activity	IBA
aldose reductase (NADPH) activity	IEA
oxidoreductase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

alcohol dehydrogenase [NAD(P)+] activity [inference]

alcohol dehydrogenase (NADP+) activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
cytosol	PMID:25294944
nucleus	FB:FBrf0161605
extracellular space	PMID:31350199
nucleoplasm	PMID:25294944
membrane	FB:FBrf0231198

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11677	MGI:1353494
Rattus norvegicus	24192	RGD:2092
Homo sapiens	231	HGNC:381
Homo sapiens	6718	HGNC:388
Homo sapiens	57016	HGNC:382
Saccharomyces cerevisiae S288C	856504	SGD:S000001146