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Guidelines

MIRAGE

C-X-C motif chemokine receptor 4

Summary

Gene Symbol

CXCR4

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 396659
PubChem: 396659

Annotation

Keyword

Cell junction
Cell membrane
Disulfide bond
Endosome
G-protein coupled receptor
Isopeptide bond
Lysosome
Phosphoprotein
Proteoglycan
Reference proteome
Sulfation
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q764M9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
response to hypoxia	IEA
chemotaxis	IEA
immune response	IBA
immune response	IEA
G protein-coupled receptor signaling pathway	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway [inference]

chemokine (C-X-C motif) ligand 12 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

C-X-C chemokine receptor CXCR4 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

chemokine-mediated signaling pathway [inference]

chemokine (C-X-C motif) ligand 12 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

C-X-C chemokine receptor CXCR4 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

calcium-mediated signaling

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

cell motility [inference]

cell migration [inference]

cell chemotaxis

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

locomotion [inference]

taxis [inference]

cell chemotaxis

response to stimulus [inference]

response to stress [inference]

response to hypoxia

immune response

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

cellular response to cytokine stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of macrophage migration inhibitory factor signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of developmental process [inference]

positive regulation of vasculature development

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of macrophage migration inhibitory factor signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of macrophage migration inhibitory factor signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of vasculature development

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

positive regulation of vasculature development

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway [inference]

chemokine (C-X-C motif) ligand 12 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

C-X-C chemokine receptor CXCR4 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

chemokine-mediated signaling pathway [inference]

chemokine (C-X-C motif) ligand 12 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

C-X-C chemokine receptor CXCR4 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of macrophage migration inhibitory factor signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of cell adhesion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

positive regulation of vasculature development

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
lysosome	ISS
lysosome	IEA
early endosome	ISS
early endosome	IEA
late endosome	ISS

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

plasma membrane

cell junction [inference]

anchoring junction

cell leading edge

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
actin binding	IEA
chemokine receptor activity	IEA
C-C chemokine receptor activity	IBA
cytokine binding	IEA
C-C chemokine binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actin binding

myosin binding [inference]

myosin light chain binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

cytokine binding

chemokine binding [inference]

C-C chemokine binding

ubiquitin-like protein binding [inference]

ubiquitin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

C-X-C motif chemokine 12 receptor activity

G protein-coupled receptor activity [inference]

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

C-X-C motif chemokine 12 receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

C-X-C motif chemokine 12 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

C-X-C chemokine receptor type 4-A

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 11 in total

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Gene Ontology
C-C chemokine binding
C-C chemokine receptor activity
brain development
calcium-mediated signaling
cell chemotaxis
chemokine receptor activity
chemokine-mediated signaling pathway
chemotaxis
immune response
neurogenesis

Displaying **all 5** entries
InterPro
CXC chemokine receptor 4 N-terminal domain
CXC chemokine receptor 4/atypical chemokine receptor 2
Chemokine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026