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hyaluronan synthase 2 S homeolog

Summary

Gene Symbol

has2.S

Organism

Xenopus laevis (African clawed frog)

External Links

NCBI Gene

399146

KEGG Gene ID

xla:399146

PubChem

399146

Alliance of Genome Resources

Xenbase:XB-GENE-5775604

Annotation

Keyword

Cell membrane
Endoplasmic reticulum
Glycosyltransferase
Golgi apparatus
Lysosome
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
V9TH72	Hyaluronate synthase 2 Hyaluronic acid synthase 2
O57427	Hyaluronate synthase 2 Hyaluronic acid synthase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
polysaccharide biosynthetic process	ISS
polysaccharide biosynthetic process	IBA
vasculogenesis	ISS
hyaluronan biosynthetic process	ISS
hyaluronan biosynthetic process	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

hyaluronan metabolic process [inference]

hyaluronan biosynthetic process

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

hyaluronan metabolic process [inference]

hyaluronan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition [inference]

cardiac epithelial to mesenchymal transition [inference]

endocardial cushion to mesenchymal transition

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal water transport [inference]

renal water absorption

regulation of urine volume [inference]

positive regulation of urine volume

renal absorption [inference]

renal water absorption

developmental process [inference]

anatomical structure development [inference]

atrioventricular canal development

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition [inference]

cardiac epithelial to mesenchymal transition [inference]

endocardial cushion to mesenchymal transition

localization [inference]

establishment of localization [inference]

transport [inference]

fluid transport [inference]

water transport [inference]

renal water transport [inference]

renal water absorption

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of urine volume [inference]

positive regulation of urine volume

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
Golgi membrane	ISS
Golgi membrane	IEA
lysosome	ISS
lysosome	IEA
endoplasmic reticulum membrane	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

extracellular vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
hyaluronan synthase activity	ISS
hyaluronan synthase activity	IBA
hyaluronan synthase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

hyaluronan synthase activity

hexosyltransferase activity [inference]

hyaluronan synthase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00752

Name

hyaluronan synthase [EC:2.4.1.212]

References

8366070

Rhea

RHEA:20465

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.212

PMID

RHEA:12528

UDP-α-D-glucuronate

H⁺ + UDP

Enzyme

2.4.1.212

PMID

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	3037	HGNC:4819
Xenopus tropicalis	100145711	Xenbase:XB-GENE-5775581

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

GlyCosmos Portal v4.5.0

Last updated: April 6, 2026

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