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lectin, mannose binding 1

Summary

Gene Symbol

LMAN1

Aliases

ERGIC-53
ERGIC53
FMFD1
MCFD1
MR60
endoplasmic reticulum-golgi intermediate compartment protein 53
gp58

Organism

Homo sapiens (human)

External Links

NCBI Gene

3998

HGNC

6631

KEGG Gene ID

hsa:3998

PubChem

3998

Alliance of Genome Resources

HGNC:6631

JoGo

LMAN1

TogoVar

LMAN1

Annotation

Keyword

3D-structure
Direct protein sequencing
Disulfide bond
ER-Golgi transport
Endoplasmic reticulum
Golgi apparatus
Lectin
Metal-binding
Phosphoprotein
Protein transport
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P49257	ER-Golgi intermediate compartment 53 kDa protein Gp58 Intracellular mannose-specific lectin MR60 Lectin mannose-binding 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
in utero embryonic development
protein folding	TAS
endoplasmic reticulum to Golgi vesicle-mediated transport	NAS
endoplasmic reticulum to Golgi vesicle-mediated transport	TAS
endoplasmic reticulum to Golgi vesicle-mediated transport	IBA

GO Hierarchy

biological process

cellular process [inference]

protein folding

intercellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

Golgi vesicle transport [inference]

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

coagulation [inference]

blood coagulation

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

animal gross anatomical part developmental process [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

protein transport

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

Golgi vesicle transport [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of protein localization to mitochondrion [inference]

negative regulation of protein localization to mitochondrion

negative regulation of protein localization [inference]

negative regulation of protein localization to mitochondrion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization

negative regulation of biological process [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to mitochondrion

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
Golgi membrane	IBA
Golgi membrane	IEA
endoplasmic reticulum	IDA
endoplasmic reticulum membrane	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

endomembrane system

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

endoplasmic reticulum-Golgi intermediate compartment membrane

sarcomere

external encapsulating structure [inference]

extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI
D-mannose binding	TAS
D-mannose binding	IBA
metal ion binding	EXP
obsolete unfolded protein binding	TAS

GO Hierarchy

molecular function

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

D-mannose binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

monosaccharide binding [inference]

D-mannose binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000074695

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K10080

Name

lectin, mannose-binding 1

References

13130098

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:2216	factor V deficiency	Alliance of Genome Resources
DOID:2211	factor XIII deficiency	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 19 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000132	Menorrhagia
HP:0000225	Gingival bleeding
HP:0000421	Epistaxis
HP:0000790	Hematuria
HP:0000978	Bruising susceptibility
HP:0001892	Abnormal bleeding
HP:0002149	Hyperuricemia
HP:0002170	Intracranial hemorrhage
HP:0002239	Gastrointestinal hemorrhage