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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

acid sensing ion channel subunit 2

Summary

Gene Symbol

ASIC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

40

KEGG Gene ID

PubChem

40

Alliance of Genome Resources

HGNC:99

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Phosphoprotein
Proteomics identification
Reference proteome
Sodium channel
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q16515	Amiloride-sensitive cation channel 1, neuronal Amiloride-sensitive cation channel neuronal 1 Brain sodium channel 1 Mammalian degenerin homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
sodium ion transport	IEA
synapse assembly
phototransduction
sensory perception of sound

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

phototransduction

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to acidic pH

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

nervous system process [inference]

nervous system process involved in regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of taste [inference]

sensory perception of sour taste

sensory perception of mechanical stimulus [inference]

sensory perception of sound

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to abiotic stimulus [inference]

response to pH [inference]

response to acidic pH [inference]

cellular response to acidic pH

cellular response to pH [inference]

cellular response to acidic pH

response to radiation [inference]

response to light stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to acidic pH

response to chemical [inference]

response to xenobiotic stimulus [inference]

cellular response to xenobiotic stimulus

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

detection of stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to acidic pH

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of ion transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of ion transmembrane transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of cellular process [inference]

signal transduction [inference]

phototransduction

regulation of transmembrane transport [inference]

regulation of ion transmembrane transport

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of biological quality [inference]

regulation of membrane potential

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
plasma membrane	EXP
plasma membrane	TAS
plasma membrane	IDA
plasma membrane	IBA
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

neuron spine [inference]

dendritic spine

cell body [inference]

neuronal cell body

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
ion channel activity	IEA
monoatomic ion channel activity	IEA
monoatomic cation channel activity	IEA
sodium channel activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity

sodium channel activity

ligand-gated sodium channel activity

pH-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

pH-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

pH-gated sodium channel activity

pH-gated monoatomic ion channel activity [inference]

pH-gated sodium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity

sodium channel activity

ligand-gated sodium channel activity

pH-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

pH-gated sodium channel activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

ligand-gated sodium channel activity

pH-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity

sodium channel activity

ligand-gated sodium channel activity

pH-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

pH-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

pH-gated sodium channel activity

pH-gated monoatomic ion channel activity [inference]

pH-gated sodium channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

pH-gated sodium channel activity

pH-gated monoatomic ion channel activity [inference]

pH-gated sodium channel activity

monoatomic ion-gated channel activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ion channel

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ligand-gated sodium channel activity
monoatomic ion transport
sodium channel activity
sodium ion transmembrane transport

Displaying 1 entry
InterPro
Epithelial sodium channel

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11418	MGI:1100867
Rattus norvegicus	25364	RGD:2017
Drosophila melanogaster	36864	FB:FBgn0024319
Danio rerio	407669	ZFIN:ZDB-GENE-040513-4

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026