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fringe

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

40314

KEGG Gene ID

dme:Dmel_CG10580

PubChem

40314

Alliance of Genome Resources

FB:FBgn0011591

Annotation

Keyword

Developmental protein
Direct protein sequencing
Disulfide bond
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q24342	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
compound eye morphogenesis	IMP
germarium-derived egg chamber formation	IMP
pattern specification process	IEA
dorsal/ventral pattern formation, imaginal disc	IDA
imaginal disc-derived wing morphogenesis	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via fucose

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via fucose

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via fucose

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via fucose

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via fucose

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via fucose

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via fucose

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

reproductive process [inference]

developmental process involved in reproduction [inference]

multicellular organismal process [inference]

pattern specification process

regionalization [inference]

imaginal disc pattern formation [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

dorsal/ventral pattern formation, imaginal disc

wing disc dorsal/ventral pattern formation

wing disc pattern formation [inference]

anterior/posterior pattern specification [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

dorsal/ventral pattern formation [inference]

dorsal/ventral pattern formation, imaginal disc

wing disc dorsal/ventral pattern formation

cuticle pattern formation

segmentation [inference]

appendage segmentation [inference]

imaginal disc-derived leg segmentation

stem cell population maintenance [inference]

germ-line stem cell population maintenance [inference]

female germ-line stem cell population maintenance

developmental process [inference]

developmental process involved in reproduction [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

imaginal disc-derived wing margin morphogenesis

post-embryonic appendage morphogenesis [inference]

animal organ morphogenesis [inference]

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

compound eye morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

anatomical structure formation involved in morphogenesis [inference]

germarium-derived egg chamber formation

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

animal organ development [inference]

sensory organ development [inference]

eye development [inference]

compound eye development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

maintenance of cell number [inference]

stem cell population maintenance [inference]

germ-line stem cell population maintenance [inference]

female germ-line stem cell population maintenance

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IDA
Golgi membrane	IEA
cytoplasm	HDA
Golgi stack	IDA
Golgi medial cisterna	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

Golgi cisterna [inference]

Golgi medial cisterna

Displaying **all 5** entries
GO Term	Evidence Code	PMID
glycosyltransferase activity	IEA
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IDA
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IBA
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IEA
metal ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

beta-1,3-n-acetylglucosaminyltransferase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
regulation of Notch signaling pathway
transferase activity

Displaying 1 entry
InterPro
Fringe-like, glycosyltransferase domain

KEGG BRITE Database

Orthology

K05948

Name

fringe [EC:2.4.1.222]

References

9187150

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
Golgi apparatus	PMID:10899003
Golgi medial cisterna	PMID:22251795
Golgi stack	PMID:11514618
endoplasmic reticulum	PMID:11514618
cytoplasm	PMID:26896675

Rhea

RHEA:70531

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.222

PMID

RHEA:70511

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.222

PMID

Ortholog

Displaying entries **1 - 10** of 14 in total

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Species	Gene ID	Alliance of Genome Resources
Mus musculus	17305	MGI:1095404
Mus musculus	16848	MGI:1095413
Mus musculus	19719	MGI:894275
Rattus norvegicus	315119	RGD:735126
Rattus norvegicus	170905	RGD:620587
Rattus norvegicus	60433	RGD:621322
Homo sapiens	4242	HGNC:7038
Homo sapiens	3955	HGNC:6560
Homo sapiens	5986	HGNC:9974
Danio rerio	30158	ZFIN:ZDB-GENE-980605-16