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latent transforming growth factor beta binding protein 1

Summary

Gene Symbol

LTBP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4052

PubChem

4052

Alliance of Genome Resources

HGNC:6714

JoGo

LTBP1

TogoVar

LTBP1

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cell surface receptor protein serine/threonine kinase signaling pathway	IEA
obsolete sequestering of TGFbeta in extracellular matrix
establishment of protein localization to extracellular region	IDA	2022183
establishment of protein localization to extracellular region	IEA	http://purl.obolibrary.org/obo/go/references/0000117
transforming growth factor beta production	IDA	2022183

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

transforming growth factor beta production

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

transforming growth factor beta production

multicellular organismal process [inference]

cytokine production [inference]

transforming growth factor beta production

localization [inference]

macromolecule localization [inference]

protein localization to extracellular region

establishment of localization [inference]

establishment of protein localization [inference]

establishment of protein localization to extracellular region

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
microfibril	IDA	12429738
microfibril	IEA	http://purl.obolibrary.org/obo/go/references/0000107 http://purl.obolibrary.org/obo/go/references/0000117
extracellular region	EXP	16157329
extracellular region	TAS	https://reactome.org/content/detail/R-HSA-2328033 https://reactome.org/content/detail/R-HSA-2395320 https://reactome.org/content/detail/R-HSA-2395328
extracellular region	IBA

GO Hierarchy

cellular component

protein-containing complex

extracellular protein-containing complex [inference]

transforming growth factor beta complex

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
transforming growth factor beta receptor activity	NAS	8537398
extracellular matrix structural constituent	RCA	20551380 23979707 25037231 28327460 28675934
calcium ion binding	IEA	http://purl.obolibrary.org/obo/go/references/0000002
protein binding	IPI	12429738 17293099 18677313 19349279 20855508 21677751 27339457 28669633
transforming growth factor beta binding	IPI	10930463 18672106 2022183 8617200

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

growth factor binding [inference]

transforming growth factor beta binding

cytokine binding [inference]

transforming growth factor beta binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

extracellular matrix binding [inference]

microfibril binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity

molecular adaptor activity

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

receptor ligand inhibitor activity

molecular sequestering activity [inference]

protein sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

latent-transforming growth factor beta-binding

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 8** entries
InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
NOTCH1 EGF-like calcium-binding domain
TB domain
TGF-beta binding (TB) domain superfamily