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latent transforming growth factor beta binding protein 2

Summary

Gene Symbol

LTBP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

4053

PubChem

4053

Alliance of Genome Resources

HGNC:6715

JoGo

LTBP2

TogoVar

LTBP2

Annotation

Keyword

Disease variant
Disulfide bond
Dwarfism
EGF-like domain
Extracellular matrix
Glaucoma
Glycoprotein
Growth factor binding
Heparin-binding
Hydroxylation
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q14767

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein targeting	TAS	7798248
transforming growth factor beta receptor signaling pathway	TAS	8697098
protein secretion	TAS	8697098
supramolecular fiber organization	IMP	24908666
supramolecular fiber organization	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

supramolecular fiber organization

export from cell [inference]

secretion by cell [inference]

protein secretion

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

protein secretion

protein localization to extracellular region [inference]

protein secretion

establishment of localization [inference]

transport [inference]

protein transport [inference]

protein secretion

secretion [inference]

secretion by cell [inference]

protein secretion

export from cell [inference]

secretion by cell [inference]

protein secretion

establishment of protein localization [inference]

protein targeting

protein transport [inference]

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	HDA	27068509
obsolete extracellular space	HDA	20551380
extracellular matrix	TAS	7798248
obsolete collagen-containing extracellular matrix	HDA	20551380 27559042 28327460
extracellular exosome	HDA	21362503 23533145

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular matrix structural constituent	RCA	20551380 27559042 28327460
calcium ion binding	IEA
protein binding	IPI	17293099 17581631
heparin binding	IEA
growth factor binding	IEA

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

growth factor binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

extracellular matrix binding [inference]

microfibril binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

latent-transforming growth factor beta-binding

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 8** entries
InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
NOTCH1 EGF-like calcium-binding domain
TB domain
TGF-beta binding (TB) domain superfamily