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Guidelines

MIRAGE

latent transforming growth factor beta binding protein 3

Summary

Gene Symbol

LTBP3

Organism

Homo sapiens (human)

External Links

NCBI Gene

4054

KEGG Gene ID

[""]

PubChem

4054

Alliance of Genome Resources

HGNC:6716

Annotation

Keyword

Alternative splicing
Amelogenesis imperfecta
Disease variant
Disulfide bond
Dwarfism
EGF-like domain
Extracellular matrix
Glycoprotein
Growth factor binding
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B9EG76
Q9NS15
Q8WYU6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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2

3

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GO Term	Evidence Code	PMID
chondrocyte differentiation
transforming growth factor beta receptor signaling pathway	IMP
transforming growth factor beta receptor signaling pathway	IBA
transforming growth factor beta receptor signaling pathway	IEA
bone mineralization

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

multicellular organismal process [inference]

tissue remodeling [inference]

bone remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

bone morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

lung saccule development

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of stem cell proliferation [inference]

positive regulation of mesenchymal stem cell proliferation

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

negative regulation of multicellular organismal process [inference]

negative regulation of ossification [inference]

negative regulation of bone mineralization

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of developmental process [inference]

regulation of cell differentiation

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

regulation of stem cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

regulation of mesenchymal stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

negative regulation of bone mineralization

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of stem cell proliferation [inference]

positive regulation of mesenchymal stem cell proliferation

regulation of stem cell proliferation [inference]

regulation of mesenchymal stem cell proliferation [inference]

positive regulation of mesenchymal stem cell proliferation

positive regulation of stem cell proliferation [inference]

positive regulation of mesenchymal stem cell proliferation

regulation of cell differentiation

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

regulation of stem cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

regulation of mesenchymal stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of stem cell proliferation [inference]

positive regulation of mesenchymal stem cell proliferation

positive regulation of cell differentiation [inference]

positive regulation of stem cell differentiation [inference]

positive regulation of mesenchymal stem cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

negative regulation of ossification [inference]

negative regulation of bone mineralization

regulation of bone mineralization [inference]

negative regulation of bone mineralization

regulation of tissue remodeling [inference]

regulation of bone remodeling [inference]

regulation of bone resorption [inference]

positive regulation of bone resorption

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

negative regulation of multicellular organismal process [inference]

negative regulation of ossification [inference]

negative regulation of bone mineralization

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

negative regulation of bone mineralization

negative regulation of biomineral tissue development [inference]

negative regulation of bone mineralization

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
extracellular region	EXP
extracellular region	TAS
extracellular region	IBA
extracellular region	IEA
extracellular region	HDA

GO Hierarchy

cellular component

protein-containing complex [inference]

extracellular protein-containing complex [inference]

transforming growth factor beta complex

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

elastic fiber

Displaying **all 4** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
protein binding	IPI
transforming growth factor beta binding	IPI
transforming growth factor beta binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

growth factor binding [inference]

transforming growth factor beta binding

cytokine binding [inference]

transforming growth factor beta binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

latent-transforming growth factor beta-binding

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0090143	brachyolmia-amelogenesis imperfecta syndrome	Alliance of Genome Resources
DOID:0111727	geleophysic dysplasia 3	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026