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acid sensing ion channel subunit 2

Summary

Gene Symbol

ASIC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

PubChem

Alliance of Genome Resources

HGNC:99

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Phosphoprotein
Reference proteome
Sodium channel
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q16515	Amiloride-sensitive brain sodium channel Amiloride-sensitive cation channel 1, neuronal Amiloride-sensitive cation channel neuronal 1 Brain sodium channel 1 Mammalian degenerin homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 22** of 22 in total

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GO Term	Evidence Code	PMID
inorganic cation transmembrane transport
regulation of postsynapse assembly	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

phototransduction

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to acidic pH

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

sodium ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

nervous system process [inference]

nervous system process involved in regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of taste [inference]

sensory perception of sour taste

sensory perception of mechanical stimulus [inference]

sensory perception of sound

developmental process [inference]

anatomical structure development [inference]

system development [inference]

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to abiotic stimulus [inference]

response to pH [inference]

response to acidic pH [inference]

cellular response to acidic pH

cellular response to pH [inference]

cellular response to acidic pH

response to radiation [inference]

response to light stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to acidic pH

response to chemical [inference]

response to xenobiotic stimulus [inference]

cellular response to xenobiotic stimulus

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

detection of stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to acidic pH

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

sodium ion transmembrane transport

establishment of localization in cell

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of ion transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of ion transmembrane transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of cellular process [inference]

signal transduction [inference]

phototransduction

regulation of transmembrane transport [inference]

regulation of ion transmembrane transport

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of biological quality [inference]

regulation of membrane potential

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
postsynaptic density membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

cell body [inference]

neuronal cell body

postsynapse [inference]

dendritic spine

Displaying **all 4** entries
GO Term	Evidence Code	PMID
voltage-gated sodium channel activity	IEA
protein binding	IPI	11802773
ligand-gated sodium channel activity	IBA
monoatomic ion-gated channel activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

monoatomic ion-gated channel activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sodium channel

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ligand-gated sodium channel activity
monoatomic ion transport
sodium channel activity
sodium ion transmembrane transport

Displaying 1 entry
InterPro
Epithelial sodium channel

Ortholog

Displaying entries **31 - 40** of 80 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Canis lupus familiaris	491150		CANLF19034
Bos taurus	617930		BOVIN12306
Macaca mulatta	718204		MACMU14518
Pan troglodytes	748244		PANTR14296
Drosophila melanogaster	791696	FB:FBgn0053289
Equus caballus	100058355		HORSE04618
Taeniopygia guttata	100229402		TAEGU15463
Callithrix jacchus	100413424		CALJA32805
Pongo abelii	100450915		PONAB12251
Ornithorhynchus anatinus	100682231		ORNAN03445

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Acknowledgements