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Guidelines

MIRAGE

alpha-Mannosidase class II a

Summary

Gene Symbol

alpha-Man-IIa

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

41126

KEGG Gene ID

PubChem

41126

Alliance of Genome Resources

FB:FBgn0011740

Annotation

Keyword

3D-structure
Disulfide bond
Glycosidase
Golgi apparatus
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q24451	Golgi alpha-mannosidase II Golgi alpha-mannosidase IIa Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
A0A0B4KFG0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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2

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GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
mannose metabolic process	IEA
N-glycan processing	IBA
glycoprotein metabolic process
rhodopsin biosynthetic process	IMP

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

encapsulation of foreign target

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

Golgi apparatus N-glycan mannose trimming

rhodopsin biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

Golgi apparatus N-glycan mannose trimming

pigment metabolic process [inference]

pigment metabolic process involved in pigmentation [inference]

pigment metabolic process involved in developmental pigmentation [inference]

eye pigment metabolic process [inference]

eye pigment biosynthetic process [inference]

rhodopsin biosynthetic process

rhodopsin metabolic process [inference]

rhodopsin biosynthetic process

pigment biosynthetic process [inference]

eye pigment biosynthetic process [inference]

rhodopsin biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

Golgi apparatus N-glycan mannose trimming

rhodopsin biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process

glycoprotein biosynthetic process [inference]

N-glycan processing

Golgi apparatus N-glycan mannose trimming

rhodopsin metabolic process [inference]

rhodopsin biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

protein metabolic process [inference]

glycoprotein metabolic process

glycoprotein biosynthetic process [inference]

N-glycan processing

Golgi apparatus N-glycan mannose trimming

rhodopsin metabolic process [inference]

rhodopsin biosynthetic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process

glycoprotein biosynthetic process [inference]

N-glycan processing

Golgi apparatus N-glycan mannose trimming

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

N-glycan processing

Golgi apparatus N-glycan mannose trimming

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IDA
Golgi membrane	IBA
Golgi membrane	IEA
endoplasmic reticulum	NAS
Golgi apparatus	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
alpha-mannosidase activity	IBA
alpha-mannosidase activity	IEA
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	IDA
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	IEA
mannosidase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

mannosidase activity

alpha-mannosidase activity

mannosyl-oligosaccharide mannosidase activity [inference]

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

binding [inference]

carbohydrate binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha mannosidase

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 6** entries
Gene Ontology
alpha-mannosidase activity
catalytic activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity
mannose metabolic process
metal ion binding

Displaying **all 9** entries
InterPro
Galactose mutarotase-like domain superfamily
Glycoside hydrolase 38, N-terminal domain superfamily
Glycoside hydrolase families 57/38, central domain superfamily
Glycoside hydrolase family 38, N-terminal domain
Glycoside hydrolase family 38, central domain superfamily
Glycoside hydrolase family 38, central domain
Glycoside hydrolase/deacetylase, beta/alpha-barrel
Glycosyl hydrolase family 38, C-terminal
Glycosyl hydrolase, all-beta

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
membrane	FB:FBrf0231198
Golgi membrane	PMID:10504337

Rhea

H₂O

α-D-mannopyranose

Enzyme

3.2.1.114

PMID

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	17158	MGI:104669
Mus musculus	140481	MGI:2150656
Rattus norvegicus	25478	RGD:3038
Caenorhabditis elegans	179632	WB:WBGene00010284
Homo sapiens	4122	HGNC:6825
Homo sapiens	4124	HGNC:6824

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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026