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mannosidase beta

Summary

Gene Symbol

MANBA

Aliases

beta-mannosidase A

Organism

Homo sapiens (human)

External Links

NCBI Gene

4126

HGNC

6831

KEGG Gene ID

["hsa:4126"]

PubChem

4126

Alliance of Genome Resources

HGNC:6831

JoGo

MANBA

TogoVar

MANBA

Annotation

Keyword

Disulfide bond
Glycoprotein
Glycosidase
Lysosome
Proteomics identification
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O00462	Lysosomal beta A mannosidase Mannanase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
glycoprotein catabolic process	ISS
glycoprotein catabolic process	IBA
oligosaccharide catabolic process	TAS
protein modification process	NAS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

protein modification process

macromolecule modification [inference]

protein modification process

primary metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process [inference]

oligosaccharide catabolic process

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

protein modification process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
lysosome	IEA
plasma membrane	TAS
azurophil granule membrane	TAS
lysosomal lumen	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

azurophil granule membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane [inference]

azurophil granule membrane

secretory granule membrane [inference]

azurophil granule membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
hydrolase activity, hydrolyzing O-glycosyl compounds	IEA
beta-mannosidase activity	TAS
beta-mannosidase activity	IDA
beta-mannosidase activity	IBA
beta-mannosidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

mannosidase activity [inference]

beta-mannosidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

beta mannosidase A

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription

Displaying **all 4** entries
Gene Ontology
beta-mannosidase activity
glycoprotein catabolic process
hydrolase activity, acting on glycosyl bonds
hydrolase activity

Displaying **all 6** entries
InterPro
Beta-Galactosidase/glucuronidase domain superfamily
Galactose-binding-like domain superfamily
Glycoside hydrolase superfamily
Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich
Immunoglobulin-like fold
Mannosidase Ig/CBM-like domain

Human Protein Atlas

ENSG00000109323

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01192

Name

beta-mannosidase [EC:3.2.1.25]

References

16844780

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3633	beta-mannosidosis	Glyco-Disease Genes Database Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 18 in total

1

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000365	Hearing impairment
HP:0000503	Tortuosity of conjunctival vessels
HP:0000718	Aggressive behavior
HP:0000752	Hyperactivity
HP:0001014	Angiokeratoma
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0001252	Hypotonia
HP:0001290	Generalized hypotonia