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Guidelines

MIRAGE

Heat shock protein 70 cognate 4

Summary

Gene Symbol

Hsc70-4

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

41840

KEGG Gene ID

PubChem

41840

Alliance of Genome Resources

FB:FBgn0266599

Annotation

Keyword

ATP-binding
Cytoplasm
Direct protein sequencing
Glycoprotein
Nucleus
Proteomics identification
Reference proteome
Stress response

Proteins

Displaying **all 2** entries
UniProt	Protein Name
C7LA75
P11147	Heat shock 70 kDa protein 88E

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
mRNA splicing, via spliceosome	IC
protein folding	IDA
response to stress	IEA
neurotransmitter secretion	IMP
neurotransmitter secretion	IGI

GO Hierarchy

biological process

cellular process [inference]

protein folding

protein refolding

cell recognition [inference]

neuron recognition [inference]

axonal fasciculation

metabolic process [inference]

catabolic process [inference]

autophagy [inference]

microautophagy [inference]

late endosomal microautophagy

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

vesicle-mediated transport

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to topologically incorrect protein

process utilizing autophagic mechanism [inference]

autophagy [inference]

microautophagy [inference]

late endosomal microautophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

neuron projection fasciculation [inference]

axonal fasciculation

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

membrane organization [inference]

membrane bending

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

reproductive process [inference]

developmental process involved in reproduction [inference]

follicle cell of egg chamber development

developmental process [inference]

developmental process involved in reproduction [inference]

follicle cell of egg chamber development

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

system development [inference]

nervous system development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

response to stimulus [inference]

response to stress

cellular response to stress [inference]

cellular response to topologically incorrect protein

response to topologically incorrect protein [inference]

cellular response to topologically incorrect protein

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to topologically incorrect protein

localization [inference]

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

vesicle-mediated transport

secretion [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

establishment of localization in cell [inference]

neurotransmitter secretion

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

post-transcriptional gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated post-transcriptional gene silencing

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
cytosol	HDA
plasma membrane	IBA
perinuclear region of cytoplasm	IEA
precatalytic spliceosome	HDA
catalytic step 2 spliceosome	HDA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

spliceosomal complex [inference]

catalytic complex [inference]

catalytic step 2 spliceosome

ribonucleoprotein complex [inference]

spliceosomal complex [inference]

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
ATP binding	IEA
ATP hydrolysis activity	IBA
ATP hydrolysis activity	IEA
heat shock protein binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein folding chaperone

ATP-dependent protein folding chaperone

ATP-dependent activity [inference]

ATP-dependent protein folding chaperone

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
catalytic step 2 spliceosome	PMID:18981222
terminal bouton	PMID:11395008
cytosol	PMID:24292889
precatalytic spliceosome	PMID:18981222
membrane	FB:FBrf0231198
nucleus	PMID:24292889

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	15481	MGI:105384
Mus musculus	15482	MGI:96231
Rattus norvegicus	108348108	RGD:1593284
Rattus norvegicus	24472	RGD:2840
Homo sapiens	3312	HGNC:5241
Homo sapiens	3306	HGNC:5235

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Last updated: April 6, 2026