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ADAM metallopeptidase domain 11

Summary

Gene Symbol

ADAM11

Organism

Homo sapiens (human)

External Links

NCBI Gene

4185

KEGG Gene ID

PubChem

4185

Alliance of Genome Resources

HGNC:189

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Cleavage on pair of basic residues
Disulfide bond
EGF-like domain
Glycoprotein
Integrin
Proteomics identification
Reference proteome
Signal
Synapse
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DKD2
O75078	Metalloproteinase-like, disintegrin-like, and cysteine-rich protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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2

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GO Term	Evidence Code	PMID
proteolysis	IBA
proteolysis	IEA
integrin-mediated signaling pathway	TAS
multicellular organismal response to stress	ISS
establishment of protein localization	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

multicellular organismal process [inference]

behavior [inference]

chemosensory behavior [inference]

behavioral response to chemical pain [inference]

behavioral response to pain [inference]

behavioral response to chemical pain [inference]

multicellular organismal response to stress

response to pain [inference]

behavioral response to pain [inference]

behavioral response to chemical pain [inference]

response to stimulus [inference]

response to stress [inference]

multicellular organismal response to stress

response to pain [inference]

behavioral response to pain [inference]

behavioral response to chemical pain [inference]

localization [inference]

establishment of localization [inference]

establishment of protein localization

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IEA
axon	IEA
extracellular matrix	ISS
presynaptic membrane	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

external encapsulating structure [inference]

extracellular matrix

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

perikaryon

Displaying **all 5** entries
GO Term	Evidence Code	PMID
metalloendopeptidase activity	IBA
metalloendopeptidase activity	IEA
integrin binding	TAS
metallopeptidase activity	TAS
metallopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Disintegrin

Functional Category

M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 9** entries
InterPro
ADAM, cysteine-rich domain
Disintegrin domain superfamily
Disintegrin domain
Disintegrin, conserved site
EGF-like domain
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin
Peptidase M12B, propeptide
Reprolysin domain, adamalysin-type

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11488	MGI:1098667
Caenorhabditis elegans	176706	WB:WBGene00006804

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements