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Submissions

heartless

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

42160

PubChem

42160

Alliance of Genome Resources

FB:FBgn0010389

Annotation

Keyword

ATP-binding
Developmental protein
Disulfide bond
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
Q07407	DmHD-38 Protein heartless Tyrosine kinase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 56 in total

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GO Term	Evidence Code	PMID
ameboidal-type cell migration	IEA
cell fate specification	IEA
mesodermal cell fate commitment	IMP	8957000 9621429 9778498
developmental process involved in reproduction	IEA
gamete generation	IEA

GO Hierarchy

biological process

immune system process [inference]

hemocyte differentiation [inference]

larval lymph gland hemocyte differentiation [inference]

plasmatocyte differentiation [inference]

lymph gland plasmatocyte differentiation

crystal cell differentiation [inference]

lymph gland crystal cell differentiation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

cell growth [inference]

developmental cell growth [inference]

glial cell growth

cellular developmental process [inference]

cell fate specification

myoblast fate specification

cell fate determination [inference]

cell differentiation [inference]

glial cell differentiation

cardiocyte differentiation [inference]

cardioblast differentiation

hemocyte differentiation [inference]

larval lymph gland hemocyte differentiation [inference]

plasmatocyte differentiation [inference]

lymph gland plasmatocyte differentiation

crystal cell differentiation [inference]

lymph gland crystal cell differentiation

stem cell differentiation [inference]

cardioblast differentiation

renal filtration cell differentiation [inference]

nephrocyte differentiation [inference]

pericardial nephrocyte differentiation

cell fate commitment [inference]

cell fate commitment involved in formation of primary germ layer [inference]

mesodermal cell fate commitment

cell development [inference]

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration

mesodermal cell migration

mesoderm migration involved in gastrulation

cell migration involved in gastrulation [inference]

mesoderm migration involved in gastrulation

muscle cell migration [inference]

myotube cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

glial cell projection elongation

reproductive process [inference]

developmental process involved in reproduction

gonadal mesoderm development

multicellular organismal reproductive process [inference]

gamete generation

multicellular organismal process [inference]

tissue migration

mesoderm migration involved in gastrulation

developmental process [inference]

developmental process involved in reproduction

gonadal mesoderm development

anatomical structure morphogenesis [inference]

tissue morphogenesis

cell projection morphogenesis [inference]

glial cell projection elongation

anatomical structure formation involved in morphogenesis

anatomical structure development [inference]

tissue development [inference]

mesoderm development [inference]

gonadal mesoderm development

mesenchyme development [inference]

gonadal mesoderm development

cell development [inference]

animal organ development

muscle organ development [inference]

visceral muscle development

larval visceral muscle development

hematopoietic or lymphoid organ development [inference]

lymph gland development

gland development [inference]

system development [inference]

central nervous system development

muscle structure development [inference]

muscle organ development [inference]

visceral muscle development

larval visceral muscle development

somatic muscle development

cellular developmental process [inference]

cell fate specification

myoblast fate specification

cell fate determination [inference]

cell differentiation [inference]

glial cell differentiation

cardiocyte differentiation [inference]

cardioblast differentiation

hemocyte differentiation [inference]

larval lymph gland hemocyte differentiation [inference]

plasmatocyte differentiation [inference]

lymph gland plasmatocyte differentiation

crystal cell differentiation [inference]

lymph gland crystal cell differentiation

stem cell differentiation [inference]

cardioblast differentiation

renal filtration cell differentiation [inference]

nephrocyte differentiation [inference]

pericardial nephrocyte differentiation

cell fate commitment [inference]

cell fate commitment involved in formation of primary germ layer [inference]

mesodermal cell fate commitment

cell development [inference]

growth [inference]

cell growth [inference]

developmental cell growth [inference]

glial cell growth

developmental growth [inference]

developmental cell growth [inference]

glial cell growth

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response

positive regulation of immune response [inference]

positive regulation of innate immune response

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of growth [inference]

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of synaptic assembly at neuromuscular junction

regulation of developmental growth [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of developmental growth [inference]

positive regulation of synaptic assembly at neuromuscular junction

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of glial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration [inference]

positive regulation of glial cell migration

regulation of glial cell migration [inference]

positive regulation of glial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of glial cell migration

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of glial cell migration

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of neuromuscular junction development [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of glial cell migration

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of defense response [inference]

positive regulation of innate immune response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response

positive regulation of immune response [inference]

positive regulation of innate immune response

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of nervous system development [inference]

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of defense response [inference]

positive regulation of innate immune response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response

positive regulation of immune response [inference]

positive regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response

positive regulation of immune response [inference]

positive regulation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of developmental growth [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of developmental growth [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of nervous system development [inference]

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of neuromuscular junction development [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of glial cell migration

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

regulation of neuromuscular junction development [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of neuromuscular junction development [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of neuromuscular junction development [inference]

positive regulation of synaptic assembly at neuromuscular junction

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration [inference]

positive regulation of glial cell migration

regulation of glial cell migration [inference]

positive regulation of glial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of glial cell migration

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly [inference]

positive regulation of synaptic assembly at neuromuscular junction

regulation of biological quality [inference]

regulation of cell shape

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GO Term	Evidence Code	PMID
plasma membrane	IDA	36898998
plasma membrane	IBA	http://purl.obolibrary.org/obo/go/references/0000033
plasma membrane	IEA	http://purl.obolibrary.org/obo/go/references/0000117
membrane	IEA
signaling receptor complex	IBA	http://purl.obolibrary.org/obo/go/references/0000033

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

membrane

plasma membrane

postsynapse [inference]

postsynapse of neuromuscular junction

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GO Term	Evidence Code	PMID
protein kinase activity	IEA
protein tyrosine kinase activity	ISS	8112607
protein tyrosine kinase activity	IEA	http://purl.obolibrary.org/obo/go/references/0000002 http://purl.obolibrary.org/obo/go/references/0000116
transmembrane receptor protein tyrosine kinase activity	IDA	15030317 15082772
transmembrane receptor protein tyrosine kinase activity	IBA	http://purl.obolibrary.org/obo/go/references/0000033

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

fibroblast growth factor receptor

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
ATP binding
fibroblast growth factor receptor activity
fibroblast growth factor receptor signaling pathway
nucleotide binding
positive regulation of cell population proliferation
transmembrane receptor protein tyrosine kinase activity

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InterPro
Fibroblast growth factor receptor family
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
plasma membrane	PMID:36898998
cytoplasm	PMID:17923096
membrane	FB:FBrf0231198

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3070	high grade glioma	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements