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neither inactivation nor afterpotential E

Summary

Gene Symbol

ninaE

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

42367

PubChem

42367

Alliance of Genome Resources

FB:FBgn0002940

Annotation

Keyword

Cell membrane
Cell projection
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Retinal protein
Transmembrane helix
Vision

Proteins

Displaying 1 entry
UniProt	Protein Name
P06002	Neither inactivation nor afterpotential E protein Outer R1-R6 photoreceptor cells opsin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	IBA
G protein-coupled receptor signaling pathway	IEA
visual perception	IEA
phototransduction	NAS	10611962
phototransduction	IMP	15917458 16049034 17452532

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

phototransduction

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

rhabdomere development

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior

visual behavior [inference]

optokinetic behavior [inference]

optomotor response

adult behavior [inference]

adult locomotory behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

cell morphogenesis involved in neuron differentiation [inference]

photoreceptor cell morphogenesis

locomotion [inference]

taxis [inference]

energy taxis [inference]

phototaxis

thermotaxis

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

thermotaxis

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

optokinetic behavior [inference]

optomotor response

response to UV [inference]

detection of UV

detection of light stimulus [inference]

phototransduction

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

cellular response to light stimulus

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

detection of stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

negative regulation of developmental process [inference]

negative regulation of retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

regulation of developmental process [inference]

regulation of retinal cell programmed cell death [inference]

regulation of compound eye retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

negative regulation of retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

negative regulation of developmental process [inference]

negative regulation of retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

phototransduction

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

regulation of retinal cell programmed cell death [inference]

regulation of compound eye retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

negative regulation of retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
early endosome	IDA	28507272
plasma membrane	IBA
membrane	IEA
inaD signaling complex	TAS	10611962
inaD signaling complex	IPI	9010208

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

inaD signaling complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

rhabdomere membrane

organelle subcompartment [inference]

endoplasmic reticulum subcompartment [inference]

subrhabdomeral cisterna

cell projection [inference]

plasma membrane bounded cell projection [inference]

rhabdomere

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

perinuclear endoplasmic reticulum

smooth endoplasmic reticulum cisterna [inference]

subrhabdomeral cisterna

Displaying **all 5** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IEA
protein binding	IPI	15014127
G protein-coupled photoreceptor activity	NAS	8338666
G protein-coupled photoreceptor activity	IMP	7759511
G protein-coupled photoreceptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled photoreceptor activity

photoreceptor activity [inference]

G protein-coupled photoreceptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Opsin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cellular response to light stimulus
phototransduction
visual perception

Displaying **all 3** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Visual pigments (opsins) retinal binding site

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
rhabdomere	PMID:18034157 PMID:1838762 PMID:1913822 PMID:25002678 PMID:28507272
early endosome	PMID:28507272
subrhabdomeral cisterna	PMID:1838762
perinuclear endoplasmic reticulum	PMID:25002678
cytoplasmic vesicle	PMID:1913822
membrane	FB:FBrf0231198

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0110372	retinitis pigmentosa 4	Alliance of Genome Resources
DOID:10584	retinitis pigmentosa	Alliance of Genome Resources
DOID:5679	retinal disease	Alliance of Genome Resources
DOID:8466	retinal degeneration	Alliance of Genome Resources