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ALG11 alpha-1,2-mannosyltransferase

Summary

Gene Symbol

ALG11

Aliases

CDG1P
GDP-Man:Man(3)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase
KIAA0266

Organism

Homo sapiens (human)

External Links

NCBI Gene

440138

GGDB ID

gg201

HGNC

32456

mRNA

NM_001004127

map

13q14.3-21.1

Protein

NP_001004127

OMIM

613666

KEGG Gene ID

hsa:440138

PubChem

440138

Alliance of Genome Resources

HGNC:32456

JoGo

ALG11

TogoVar

ALG11

Annotation

Keyword

Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Glycosyltransferase
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q2TAA5	Asparagine-linked glycosylation protein 11 homolog Glycolipid 2-alpha-mannosyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein N-linked glycosylation	IMP	20080937
dolichol-linked oligosaccharide biosynthetic process	IMP	20080937
dolichol-linked oligosaccharide biosynthetic process	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS	https://reactome.org/content/detail/R-HSA-4551297
endoplasmic reticulum membrane	IDA	20080937
endoplasmic reticulum membrane	IBA
endoplasmic reticulum membrane	IEA	http://purl.obolibrary.org/obo/go/references/0000044
membrane	HDA	19946888

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
alpha-1,2-mannosyltransferase activity	TAS	https://reactome.org/content/detail/R-HSA-4551297
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity	IDA	20080937
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity	IBA
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity	IEA	http://purl.obolibrary.org/obo/go/references/0000002 http://purl.obolibrary.org/obo/go/references/0000003 http://purl.obolibrary.org/obo/go/references/0000116
protein binding	IPI	33961781

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

hexosyltransferase activity [inference]

mannosyltransferase activity [inference]

alpha-1,2-mannosyltransferase activity

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity

GlcNAc(2)-PP-Dol mannosyltransferase activity [inference]

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

gdp-man:man(3)glcnac(2)-pp-dol alpha-1,2-mannosyltransferase

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
GDP-Man
oligosaccharide-lipid intermediate biosynthetic process
protein N-linked glycosylation
transferase activity

Displaying **all 3** entries
InterPro
ALG11 mannosyltransferase, N-terminal
ALG11 mannosyltransferase
Glycosyl transferase, family 1

Human Protein Atlas

ENSG00000253710

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg201

Gene Symbol

ALG11

Reactions

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
GDP-Man	G35257SQ		G59406KS
GDP-Man	G43547MI		G35257SQ

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
GDP-Man	G35257SQ		G59406KS
GDP-Man	G43547MI		G35257SQ

Orthologous Gene

Displaying **all 5** entries
Species	Protein	mRNA
Drosophila melanogaster	NP_649340	NM_141083
Caenorhabditis elegans	NP_498606	NM_066205
Mus musculus	NP_898965	NM_183142
Saccharomyces cerevisiae	NP_014350	NC_001146
Rattus norvegicus	XP_341460	XM_341459

KEGG BRITE Database

Orthology

K03844

Name

alpha-1,2-mannosyltransferase [EC:2.4.1.131]

References

11278778

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R06127	2.4.1.131	G43547MI	G35257SQ
R06128	2.4.1.131	G35257SQ	G59406KS

Rhea

RHEA:29523

GDP-α-D-mannose

H⁺ + GDP

Enzyme

2.4.1.131

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080567	congenital disorder of glycosylation Ip	Glyco-Disease Genes Database Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 52 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000278	Retrognathia
HP:0000294	Low anterior hairline
HP:0000343	Long philtrum
HP:0000348	High forehead
HP:0000365	Hearing impairment
HP:0000407	Sensorineural hearing impairment
HP:0000486	Strabismus
HP:0000504	Abnormality of vision