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SREBF chaperone S homeolog

Summary

Gene Symbol

scap.S

Organism

Xenopus laevis (African clawed frog)

External Links

NCBI Gene

443598

KEGG Gene ID

PubChem

443598

Alliance of Genome Resources

Xenbase:XB-GENE-996524

Annotation

Keyword

Cholesterol metabolism
Cytoplasmic vesicle
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Lipid-binding
Reference proteome
Repeat
Transmembrane helix
WD repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
A0JPH4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cholesterol metabolic process	ISS
SREBP signaling pathway	ISS
SREBP signaling pathway	IEA
regulation of cholesterol biosynthetic process	IBA
regulation of cholesterol biosynthetic process	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cellular localization [inference]

intracellular transport [inference]

COPII-coated vesicle cargo loading

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

response to stimulus [inference]

response to stress [inference]

response to sterol depletion [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle cargo loading [inference]

COPII-coated vesicle cargo loading

intracellular transport [inference]

COPII-coated vesicle cargo loading

establishment of localization in cell [inference]

intracellular transport [inference]

COPII-coated vesicle cargo loading

cellular localization [inference]

intracellular transport [inference]

COPII-coated vesicle cargo loading

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
Golgi membrane	ISS
Golgi membrane	IEA
endoplasmic reticulum membrane	ISS
endoplasmic reticulum membrane	IBA
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

SREBP-SCAP complex

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
sterol binding	ISS
sterol binding	IEA

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

steroid binding [inference]

sterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sterol regulatory element-binding protein cleavage-activating protein

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
lipid binding
lipid metabolic process
regulation of cholesterol biosynthetic process

Displaying **all 4** entries
InterPro
Sterol regulatory element-binding protein cleavage-activating protein
Sterol-sensing domain
WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily