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complement C5a receptor 2

Summary

Gene Symbol

C5ar2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

445269

KEGG Gene ID

PubChem

445269

Alliance of Genome Resources

RGD:1303027

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q695P6	Complement component 5a receptor 2 G-protein coupled receptor 77
A6J8A1	Complement component 5a receptor 2 G-protein coupled receptor 77
Q5XPY4	Complement component 5a receptor 2 G-protein coupled receptor 77
A0A8L2QZB1	Complement component 5a receptor 2 G-protein coupled receptor 77

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

1

2

3

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GO Term	Evidence Code	PMID
complement receptor mediated signaling pathway	IBA
inflammatory response	IBA
G protein-coupled receptor signaling pathway	TAS
G protein-coupled receptor signaling pathway	IEA
phospholipase C-activating G protein-coupled receptor signaling pathway	IBA

GO Hierarchy

biological process

immune system process [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

G protein-coupled receptor signaling pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil migration [inference]

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil migration [inference]

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement component C5a signaling pathway

G protein-coupled receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

regulation of interleukin-8 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

negative regulation of tumor necrosis factor production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

regulation of interleukin-8 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

negative regulation of tumor necrosis factor production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil migration [inference]

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

regulation of interleukin-8 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

negative regulation of tumor necrosis factor production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor superfamily cytokine production [inference]

negative regulation of tumor necrosis factor production

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IBA
plasma membrane	IEA
basal plasma membrane	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

apical part of cell

Displaying **all 4** entries
GO Term	Evidence Code	PMID
complement component C5a receptor activity	IBA
G protein-coupled receptor activity	TAS
G protein-coupled receptor activity	IBA
G protein-coupled receptor activity	IEA

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

opsonin receptor activity [inference]

complement component C5a receptor activity

complement receptor activity [inference]

complement component C5a receptor activity

G protein-coupled receptor activity

immune receptor activity [inference]

complement receptor activity [inference]

complement component C5a receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G-protein coupled

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
inflammatory response
phospholipase C-activating G protein-coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration

Displaying **all 3** entries
InterPro
Formyl peptide receptor-related
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	319430	MGI:2442013
Homo sapiens	27202	HGNC:4527

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements