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hydroxysteroid 11-beta dehydrogenase 1

Summary

Gene Symbol

HSD11B1

Organism

Canis lupus familiaris (dog)

External Links

NCBI Gene: 449023
KEGG Gene ID: cfa:449023
PubChem: 449023

Annotation

Keyword

Oxidoreductase
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q5XX84	7-oxosteroid reductase Corticosteroid 11-beta-dehydrogenase isozyme 1
A0A8C0NKS2	7-oxosteroid reductase Corticosteroid 11-beta-dehydrogenase isozyme 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
steroid catabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process

lipid catabolic process [inference]

steroid catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process

lipid catabolic process [inference]

steroid catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA	30032202
intracellular membrane-bounded organelle	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
steroid binding	IEA	30032202
11-beta-hydroxysteroid dehydrogenase (NADP+) activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity [inference]

11-beta-hydroxysteroid dehydrogenase (NADP+) activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity [inference]

11-beta-hydroxysteroid dehydrogenase (NADP+) activity

binding [inference]

lipid binding [inference]

steroid binding

organic cyclic compound binding [inference]

steroid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
oxidoreductase activity

Displaying **all 2** entries
InterPro
NAD(P)-binding domain superfamily
Short-chain dehydrogenase/reductase SDR

KEGG BRITE Database

Orthology

K15680

Name

corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]

References

Rhea

RHEA:20233

a 7β-hydroxysteroid + NADP⁺

H⁺ + a 7-oxosteroid + NADPH

Enzyme

1.1.1.201

PMID

RHEA:11388

an 11β-hydroxysteroid + NADP⁺

H⁺ + an 11-oxosteroid + NADPH

Enzyme

1.1.1.146

PMID

Ortholog

Displaying entries **21 - 30** of 72 in total

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Species	Gene ID	Orthologous MAtrix
Anolis carolinensis	100555338	ANOCA06376
Loxodonta africana	100667019	LOXAF14471
Cricetulus griseus	100762502	CRIGR04953
Sarcophilus harrisii	100923255	SARHA02988
Otolemur garnettii	100966089	OTOGA02978
Pan paniscus	100981291	PANPA03686
Papio anubis	101003905	PAPAN21778
Saimiri boliviensis boliviensis	101040472	SAIBB17379
Gorilla gorilla gorilla	101147766	GORGO17892
Tursiops truncatus	101317681	TURTR07026

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Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements