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complement C6

Summary

Gene Symbol

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 449612
PubChem: 449612

Annotation

Keyword

Calcium
Disulfide bond
EGF-like domain
Glycoprotein
Membrane attack complex
Metal-binding
Reference proteome
Repeat
Secreted
Signal
Sushi
Target cell membrane
Transmembrane beta strand

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A2J8QA94
P61134

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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2

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GO Term	Evidence Code	PMID
in utero embryonic development
positive regulation of activation of membrane attack complex
complement activation	ISS	http://purl.obolibrary.org/obo/go/references/0000024
complement activation	IBA	http://purl.obolibrary.org/obo/go/references/0000033
complement activation	IEA	30032202 http://purl.obolibrary.org/obo/go/references/0000107

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, GZMK pathway

cellular process [inference]

cell killing [inference]

killing of cells of another organism

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, GZMK pathway

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, GZMK pathway

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, GZMK pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, GZMK pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, GZMK pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

positive regulation of activation of membrane attack complex

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

regulation of immune response [inference]

regulation of humoral immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

positive regulation of activation of membrane attack complex

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

regulation of immune response [inference]

regulation of humoral immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

positive regulation of activation of membrane attack complex

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane attack complex	IBA	http://purl.obolibrary.org/obo/go/references/0000033
membrane attack complex	IEA	22301074 30032202 http://purl.obolibrary.org/obo/go/references/0000002 http://purl.obolibrary.org/obo/go/references/0000107 http://purl.obolibrary.org/obo/go/references/0000117
obsolete extracellular space
other organism cell membrane	IEA	http://purl.obolibrary.org/obo/go/references/0000107 http://purl.obolibrary.org/obo/go/references/0000117
transmembrane transporter complex

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex [inference]

membrane attack complex

plasma membrane protein complex [inference]

membrane attack complex

transmembrane transporter complex

transporter complex [inference]

transmembrane transporter complex

cellular anatomical structure [inference]

other organism part [inference]

other organism cell membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IEA	22301074
metal ion binding

GO Hierarchy

molecular function

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

complement C6

Functional Category

K: Transcription
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 4** entries
Gene Ontology
complement activation, classical pathway
complement activation
immune response
immune system process

Displaying entries **1 - 10** of 13 in total

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InterPro
Complement component C6, KAZAL domain
Complement components C8A/B/C6, EGF-like domain
Factor I / membrane attack complex
LDL receptor-like superfamily
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
Membrane attack complex component/perforin (MACPF) domain
Membrane attack complex component/perforin domain, conserved site
Membrane attack complex component/perforin/complement C9
Sushi/SCR/CCP domain