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frizzled

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

45307

KEGG Gene ID

PubChem

45307

Alliance of Genome Resources

FB:FBgn0001085

Annotation

Keyword

Cell membrane
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix
Wnt signaling pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P18537	Frizzled-1
M9PFL6	Frizzled-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 36 in total

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GO Term	Evidence Code	PMID
establishment of planar polarity	IMP
establishment of imaginal disc-derived wing hair orientation	IMP
morphogenesis of a polarized epithelium	IMP
compound eye morphogenesis	IMP
homophilic cell-cell adhesion	IMP

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

homophilic cell-cell adhesion

establishment or maintenance of cell polarity

establishment of cell polarity

establishment of monopolar cell polarity [inference]

establishment of proximal/distal cell polarity [inference]

imaginal disc-derived wing hair site selection

establishment of ommatidial planar polarity

establishment or maintenance of monopolar cell polarity [inference]

establishment of monopolar cell polarity [inference]

establishment of proximal/distal cell polarity [inference]

imaginal disc-derived wing hair site selection

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway

G protein-coupled receptor signaling pathway

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification

cardiac cell fate specification [inference]

cardioblast cell fate specification

cell fate determination [inference]

cell fate determination involved in pattern specification [inference]

sensory organ precursor cell fate determination

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

compound eye photoreceptor cell differentiation [inference]

R3/R4 cell differentiation

cell fate commitment [inference]

neuron fate commitment [inference]

photoreceptor cell fate commitment [inference]

eye photoreceptor cell fate commitment [inference]

compound eye photoreceptor fate commitment [inference]

R3/R4 cell fate commitment

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

follicle cell of egg chamber migration [inference]

border follicle cell migration

cell division [inference]

asymmetric cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

non-sensory hair organization [inference]

imaginal disc-derived wing hair organization

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

periodic partitioning [inference]

segment polarity determination

cuticle pattern formation [inference]

chitin-based larval cuticle pattern formation

ommatidial rotation

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

germ-line stem-cell niche homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity

post-embryonic animal morphogenesis [inference]

animal organ morphogenesis [inference]

gland morphogenesis [inference]

salivary gland morphogenesis

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

compound eye morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a polarized epithelium

anatomical structure development [inference]

tube development [inference]

digestive tract development [inference]

midgut development

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification

cardiac cell fate specification [inference]

cardioblast cell fate specification

cell fate determination [inference]

cell fate determination involved in pattern specification [inference]

sensory organ precursor cell fate determination

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

compound eye photoreceptor cell differentiation [inference]

R3/R4 cell differentiation

cell fate commitment [inference]

neuron fate commitment [inference]

photoreceptor cell fate commitment [inference]

eye photoreceptor cell fate commitment [inference]

compound eye photoreceptor fate commitment [inference]

R3/R4 cell fate commitment

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

germ-line stem-cell niche homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of hemocyte proliferation

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

regulation of developmental growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

regulation of locomotion [inference]

regulation of chemotaxis [inference]

regulation of axon guidance [inference]

positive regulation of axon guidance

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of axon guidance

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of chemotaxis [inference]

regulation of axon guidance [inference]

positive regulation of axon guidance

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of hemocyte proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of developmental growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of developmental growth [inference]

positive regulation of axon extension

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway

G protein-coupled receptor signaling pathway

regulation of cell population proliferation [inference]

regulation of hemocyte proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of axon guidance

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of axon guidance

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development [inference]

positive regulation of axon guidance

regulation of axonogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of axon guidance [inference]

positive regulation of axon guidance

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of axon guidance

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of multicellular organismal process [inference]

regulation of hemocyte proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension

regulation of biological quality [inference]

regulation of tube architecture, open tracheal system [inference]

regulation of tube size, open tracheal system [inference]

regulation of tube length, open tracheal system

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube size, open tracheal system [inference]

regulation of tube length, open tracheal system

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
endosome	IDA
plasma membrane	TAS
plasma membrane	IDA
plasma membrane	IBA
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
Wnt receptor activity	IDA
Wnt receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

Wnt-protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
plasma membrane	PMID:16163385 PMID:8199049
endosome	PMID:16459300

Ortholog

Displaying **all 9** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	14369	MGI:108570
Mus musculus	14362	MGI:1196625
Mus musculus	57265	MGI:1888513
Rattus norvegicus	64512	RGD:71012
Caenorhabditis elegans	172856	WB:WBGene00003397
Homo sapiens	8321	HGNC:4038
Homo sapiens	2535	HGNC:4040
Homo sapiens	8324	HGNC:4045
Xenopus tropicalis	549495	Xenbase:XB-GENE-483731

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements