GlyCosmos Portal

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GO Term	Evidence Code	PMID
purine-specific mismatch base pair DNA N-glycosylase activity	IMP	20848659
purine-specific mismatch base pair DNA N-glycosylase activity	IBA
protein binding	IPI	11801590 25416956
DNA N-glycosylase activity	TAS
oxidized purine DNA binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

mismatch base pair DNA N-glycosylase activity [inference]

purine-specific mismatch base pair DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized purine nucleobase lesion DNA N-glycosylase activity [inference]

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA N-glycosylase activity

mismatch base pair DNA N-glycosylase activity [inference]

purine-specific mismatch base pair DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized purine nucleobase lesion DNA N-glycosylase activity [inference]

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

mismatch repair complex binding [inference]

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

4 iron, 4 sulfur cluster binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding [inference]

oxidized DNA binding [inference]

oxidized purine DNA binding

double-stranded DNA binding [inference]

mismatched DNA binding [inference]

adenine/guanine mispair binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

adenine DNA glycosylase

Functional Category

L: Replication, recombination and repair
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying entries **1 - 10** of 12 in total

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Gene Ontology
4 iron, 4 sulfur cluster binding
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
DNA repair
adenine/guanine mispair binding
base-excision repair
catalytic activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity
iron-sulfur cluster binding
metal ion binding

Displaying **all 7** entries
InterPro
Adenine DNA glycosylase, C-terminal
Adenine/Thymine-DNA glycosylase
DNA glycosylase
Endonuclease III-like, iron-sulphur cluster loop motif
Helix-hairpin-helix, base-excision DNA repair, C-terminal
HhH-GPD domain
NUDIX hydrolase-like domain superfamily

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050424	familial adenomatous polyposis	Alliance of Genome Resources
DOID:0080410	familial adenomatous polyposis 2	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:5517	stomach carcinoma	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **11 - 20** of 61 in total

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HPO ID	HPO Term
HP:0001260	Dysarthria
HP:0001276	Hypertonia
HP:0001288	Gait disturbance
HP:0001371	Flexion contracture
HP:0001402	Hepatocellular carcinoma
HP:0001442	Typified by somatic mosaicism
HP:0001824	Weight loss
HP:0002017	Nausea and vomiting
HP:0002019	Constipation
HP:0002024	Malabsorption

Displaying **all 4** entries
Disease ID	Disease Name
OMIM:608456	familial adenomatous polyposis 2
ORPHA:440437	familial colorectal cancer type X
ORPHA:247798	familial adenomatous polyposis 2
OMIM:613659	gastric cancer