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paraoxonase 3

Summary

Gene Symbol

PON3

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 463548
PubChem: 463548

Annotation

Keyword

Calcium
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A6D2Y4U5
A0A2I3SMF6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
renal sodium ion transport
response to toxic substance	IEA	30032202
negative regulation of superoxide anion generation
carboxylic acid catabolic process
establishment of localization in cell

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

heterocycle catabolic process [inference]

lactone catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organic cyclic compound catabolic process [inference]

lactone catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

heterocycle catabolic process [inference]

lactone catabolic process

heterocycle metabolic process [inference]

heterocycle catabolic process [inference]

lactone catabolic process

lactone metabolic process [inference]

lactone catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

organic cyclic compound metabolic process [inference]

lactone metabolic process [inference]

lactone catabolic process

organic cyclic compound catabolic process [inference]

lactone catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organic cyclic compound catabolic process [inference]

lactone catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

heterocycle catabolic process [inference]

lactone catabolic process

heterocycle metabolic process [inference]

heterocycle catabolic process [inference]

lactone catabolic process

lactone metabolic process [inference]

lactone catabolic process

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal sodium ion transport

response to stimulus [inference]

response to chemical [inference]

response to toxic substance

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

renal sodium ion transport

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

negative regulation of superoxide anion generation

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of response to stimulus [inference]

regulation of response to drug [inference]

regulation of cellular response to drug

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

negative regulation of superoxide anion generation

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of cellular response to drug

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA	22301074
extracellular space	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
arylesterase activity	IEA	22301074 30032202
protein homodimerization activity
metal ion binding
acyl-L-homoserine-lactone lactonohydrolase activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

arylesterase activity

lactonohydrolase activity [inference]

acyl-L-homoserine-lactone lactonohydrolase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serum paraoxonase/arylesterase

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
arylesterase activity
hydrolase activity
metal ion binding
response to toxic substance

Displaying **all 2** entries
InterPro
Arylesterase
Six-bladed beta-propeller, TolB-like

Ortholog

Displaying entries **11 - 20** of 54 in total

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Species	Gene ID	Orthologous MAtrix
Nomascus leucogenys	100603110	NOMLE03139
Loxodonta africana	100675274	LOXAF17691
Cavia porcellus	100721546	CAVPO06115
Cricetulus griseus	100762826	CRIGR15698
Otolemur garnettii	100958123	OTOGA17918
Pan paniscus	100971959	PANPA36665
Papio anubis	101003014	PAPAN30803
Papio anubis	101003347	PAPAN30803
Saimiri boliviensis boliviensis	101047829	SAIBB02495
Felis catus	101091774	FELCA05543