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myosin VI

Summary

Gene Symbol

MYO6

Organism

Homo sapiens (human)

External Links

NCBI Gene

4646

PubChem

4646

Alliance of Genome Resources

HGNC:7605

JoGo

MYO6

TogoVar

MYO6

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
intracellular protein transport	ISS	http://purl.obolibrary.org/obo/go/references/0000024
endocytosis	ISS	http://purl.obolibrary.org/obo/go/references/0000024
endocytosis	IMP	15247260
endocytosis	IBA	http://purl.obolibrary.org/obo/go/references/0000033
endocytosis	IEA	http://purl.obolibrary.org/obo/go/references/0000117

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

vesicle-mediated transport in synapse [inference]

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

actin filament-based process [inference]

actin filament-based movement

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

mechanoreceptor differentiation [inference]

inner ear receptor cell differentiation [inference]

inner ear auditory receptor cell differentiation

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

septin cytoskeleton organization [inference]

septin ring organization

supramolecular fiber organization [inference]

actin filament organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

inner ear morphogenesis

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

mechanoreceptor differentiation [inference]

inner ear receptor cell differentiation [inference]

inner ear auditory receptor cell differentiation

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

response to chemical [inference]

response to xenobiotic stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

localization [inference]

macromolecule localization [inference]

intracellular protein localization

protein transport

intracellular protein transport

establishment of localization [inference]

transport [inference]

protein transport

intracellular protein transport

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

vesicle-mediated transport in synapse [inference]

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

intracellular transport [inference]

intracellular protein transport

import into cell [inference]

endocytosis

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

establishment of protein localization [inference]

protein transport

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

presynaptic modulation of chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

presynaptic modulation of chemical synaptic transmission

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

postsynaptic neurotransmitter receptor internalization

Displaying entries **1 - 5** of 55 in total

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GO Term	Evidence Code	PMID
ruffle	IDA	16507995 9852149
ruffle	IBA	http://purl.obolibrary.org/obo/go/references/0000033
nucleus	EXP	16949370
nucleus	IDA	16507995
nucleus	IEA	http://purl.obolibrary.org/obo/go/references/0000044

GO Hierarchy

cellular component

protein-containing complex [inference]

myosin complex

unconventional myosin complex

filamentous actin

cellular anatomical structure [inference]

nucleoplasm

cytoplasm

cell cortex

cytosol

membrane

organelle membrane [inference]

vesicle membrane

cytoplasmic vesicle membrane [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

nuclear membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

cell junction [inference]

synapse [inference]

ribbon synapse [inference]

cochlear hair cell ribbon synapse

leading edge membrane [inference]

ruffle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

ruffle

neuron projection [inference]

axon

actin-based cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle

clathrin-coated endocytic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

autophagosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle

clathrin-coated endocytic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

postsynaptic actin cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

autophagosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle

clathrin-coated endocytic vesicle

intracellular membraneless organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

postsynaptic actin cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

cluster of actin-based cell projections [inference]

brush border

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
microfilament motor activity	IBA
cytoskeletal motor activity	ISS	http://purl.obolibrary.org/obo/go/references/0000024
cytoskeletal motor activity	IEA	http://purl.obolibrary.org/obo/go/references/0000002 http://purl.obolibrary.org/obo/go/references/0000104
actin binding	TAS	10519557
protein binding	IPI	11447109 11967127 15247260 15837803 16908842 22323290 23023224 28514442 29467281 33961781 35271311 40205054

GO Hierarchy

molecular function

cytoskeletal motor activity

microfilament motor activity

minus-end directed microfilament motor activity

catalytic activity [inference]

isomerase activity [inference]

macromolecular conformation isomerase activity [inference]

polypeptide conformation or assembly isomerase activity [inference]

microfilament motor activity

minus-end directed microfilament motor activity

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

identical protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

ADP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

actin filament binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

microfilament motor activity

minus-end directed microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

myosin I

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
actin binding
actin filament binding
actin filament organization
cytoskeletal motor activity
nucleotide binding
vesicle transport along actin filament

Displaying **all 3** entries
InterPro
Kinesin motor domain superfamily
Myosin head, motor domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0110495	autosomal recessive nonsyndromic deafness 37	Alliance of Genome Resources
DOID:0110552	autosomal dominant nonsyndromic deafness 22	Alliance of Genome Resources
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources
DOID:2394	ovarian cancer	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

OrthoDB (Group)

International Collaboration

Acknowledgements