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Guidelines

MIRAGE

MHC class II DLA DRB1 beta chain

Summary

Gene Symbol

DLA-DRB1

Organism

Canis lupus familiaris (dog)

External Links

NCBI Gene: 474860
PubChem: 474860

Annotation

Keyword

Disulfide bond
Glycoprotein
MHC II
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P18470

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
positive regulation of immune response
positive regulation of T cell activation	IEA	30032202

GO Hierarchy

biological process

immune system process [inference]

production of molecular mediator of immune response [inference]

immunoglobulin production [inference]

immunoglobulin production involved in immunoglobulin-mediated immune response

immune response

adaptive immune response

antigen processing and presentation [inference]

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

immunoglobulin production [inference]

immunoglobulin production involved in immunoglobulin-mediated immune response

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

immunoglobulin production [inference]

immunoglobulin production involved in immunoglobulin-mediated immune response

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

immunoglobulin production [inference]

immunoglobulin production involved in immunoglobulin-mediated immune response

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

immunoglobulin production [inference]

immunoglobulin production involved in immunoglobulin-mediated immune response

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

immunoglobulin production [inference]

immunoglobulin production involved in immunoglobulin-mediated immune response

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

production of molecular mediator of immune response [inference]

immunoglobulin production [inference]

immunoglobulin production involved in immunoglobulin-mediated immune response

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class II protein complex

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class II protein complex

response to stimulus [inference]

immune response

adaptive immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of immune response

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of immune response [inference]

positive regulation of immune response

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of immune response

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of response to stimulus [inference]

positive regulation of immune response

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response

regulation of immune response [inference]

positive regulation of immune response

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
lysosomal membrane	IEA	30032202
late endosome membrane	IEA	30032202
MHC class II protein complex	IEA	22301074 30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

MHC protein complex [inference]

MHC class II protein complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
MHC class II protein complex binding	IEA	30032202
peptide antigen binding

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

peptide antigen binding

amide binding [inference]

peptide binding [inference]

peptide antigen binding

protein-containing complex binding [inference]

MHC protein complex binding [inference]

MHC class II protein complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

HLA class II histocompatibility antigen, DO beta chain

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
immune response

Displaying **all 4** entries
InterPro
Immunoglobulin C1-set
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Ortholog

Displaying entries **31 - 40** of 96 in total

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Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Gorilla gorilla gorilla	101131235		GORGO37614
Oryzias latipes	101156391		ORYLA12012
Oryzias latipes	101163710		ORYLA19342
Octodon degus	101561716		OCTDE02126
Octodon degus	101565277		OCTDE02127
Jaculus jaculus	101593689		JACJA25118
Ictidomys tridecemlineatus	101968188		ICTTR17640
Chinchilla lanigera	102019638		CHILA10108
Chinchilla lanigera	102019954		CHILA10113
Chinchilla lanigera	102020606		CHILA10113

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025