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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

Summary

Gene Symbol

PFKFB2

Organism

Canis lupus familiaris (dog)

External Links

NCBI Gene: 480011
KEGG Gene ID: cfa:480011
PubChem: 480011

Annotation

Keyword

Acetylation
Kinase
Multifunctional enzyme
Nucleotide-binding
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A8C0SNE0	6PF-2-K/Fru-2,6-P2ase heart-type isozyme
A0A8I3MJJ0	6PF-2-K/Fru-2,6-P2ase heart-type isozyme
A0A8C0SM64	6PF-2-K/Fru-2,6-P2ase heart-type isozyme
A0A8I3MEI5	6PF-2-K/Fru-2,6-P2ase heart-type isozyme

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
fructose metabolic process	IEA	22301074
fructose 2,6-bisphosphate metabolic process	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

carbohydrate derivative metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytosol	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying **all 3** entries
GO Term	Evidence Code	PMID
6-phosphofructo-2-kinase activity	IEA	22301074 30032202
fructose-2,6-bisphosphate 2-phosphatase activity	IEA	30032202
ATP binding	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

carbohydrate kinase activity [inference]

phosphofructokinase activity [inference]

6-phosphofructo-2-kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

phosphofructokinase activity [inference]

6-phosphofructo-2-kinase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

fructose-2,6-bisphosphate 2-phosphatase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

6-phosphofructo-2-kinase/fructose-2

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 7** entries
Gene Ontology
6-phosphofructo-2-kinase activity
ATP binding
carbohydrate phosphorylation
catalytic activity
fructose 2,6-bisphosphate metabolic process
fructose metabolic process
nucleotide binding

Displaying **all 6** entries
InterPro
6-phosphofructo-2-kinase
Fructose-2,6-bisphosphatase
Histidine phosphatase superfamily, clade-1
Histidine phosphatase superfamily
P-loop containing nucleoside triphosphate hydrolase
Phosphoglycerate/bisphosphoglycerate mutase, active site

KEGG BRITE Database

Orthology

K19029

Name

6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 2 [EC:2.7.1.105 3.1.3.46]

References

8814283

Rhea

RHEA:17289

H₂O + β-D-fructose 2,6-bisphosphate

phosphate + β-D-fructose 6-phosphate

Enzyme

3.1.3.46

PMID

RHEA:15653

ATP + β-D-fructose 6-phosphate

H⁺ + ADP + β-D-fructose 2,6-bisphosphate

Enzyme

2.7.1.105

PMID

Ortholog

Displaying entries **41 - 50** of 85 in total

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Species	Gene ID	Orthologous MAtrix
Chlorocebus sabaeus	103230179	CHLSB11992
Poecilia reticulata	103464749	POERE26920
Ursus maritimus	103657667	URSMA23088
Serinus canaria	103822399	SERCA19045
Rhinopithecus roxellana	104664186	RHIRO12274
Esox lucius	105017284	ESOLU51665
Pteropus vampyrus	105308916	PTEVA09095
Macaca nemestrina	105484866	MACNE03092
Mandrillus leucophaeus	105529742	MANLE37318
Cercocebus atys	105576814	CERAT25605

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